Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

12 citing papers in PubMed.

1. RagC and Map4K3 deficiency in high-grade gliomas drives proliferation and modulates mTORC1-dependent cellular functions.Journal of neuropathology and experimental neurology · 2026
   Article
2. Lysosomal phosphoinositide turnover acts upstream of RagGTPase-mTORC1 and controls muscle growth.Nature metabolism · 2026
   Article
3. The Role of Mammalian Target of Rapamycin (mTOR) and Adenosine Monophosphate-Activated Protein Kinase (AMPK) Signaling in Skeletal Muscle Hypertrophy: A Literature Review With Implications for Health and Disease.Cureus · 2025
   Review
4. The Amino Acid Permease MoGap1 Regulates TOR Activity and Autophagy inInternational journal of molecular sciences · 2022
   Article
5. Ait1 regulates TORC1 signaling and localization in budding yeast.eLife · 2022
   Article
6. O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine.Nature communications · 2022
   Article
7. The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction.Developmental cell · 2020
   Article
8. mTOR at the nexus of nutrition, growth, ageing and disease.Nature reviews. Molecular cell biology · 2020
   Review
9. Nutrient regulation of mTORC1 at a glance.Journal of cell science · 2019
   Review
10. Oncogenic Rag GTPase signaling enhances B cell activation and drives follicular lymphoma sensitive to pharmacological inhibition of mTOR.Nature metabolism · 2019
    Article
11. Targeting the mTOR Signaling Pathway Utilizing Nanoparticles: A Critical Overview.Cancers · 2019
    Review
12. Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.Nature · 2018
    Article

Corrections and comments

• Erratum for
  Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.2017

Authors and funding

3 authors.

Funding

Abstract

PubMed holds no abstract for this paper.