ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2017
Autoregulation in paediatric TBI-current evidence and implications for treatment.
Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Visualizations of autoregulatory insults in moderate-to-severe paediatric traumatic brain injury: a secondary analysis from the multicentre STARSHIP trial.Critical care (London, England) · 2025Article
- Cerebral autoregulation in pediatric and neonatal intensive care: A scoping review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Monitoring of cerebral blood flow autoregulation: physiologic basis, measurement, and clinical implications.British journal of anaesthesia · 2024Review
- Perioperative Neuromonitoring in Children with Congenital Heart Disease.Neurocritical care · 2024Review
- Neuromonitoring in Children with Traumatic Brain Injury.Neurocritical care · 2024Review
- Intracranial Pressure and Its Related Parameters in the Management of Severe Pediatric Traumatic Brain Injury.Advances in neurobiology · 2024Review
- Can a Therapeutic Strategy for Hypotension Improve Cerebral Perfusion and Oxygenation in an Experimental Model of Hemorrhagic Shock and Severe Traumatic Brain Injury?Neurocritical care · 2023Article
- ICP, PRx, CPP, and ∆CPPopt in pediatric traumatic brain injury: the combined effect of insult intensity and duration on outcome.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Observational
- Advanced Neuromonitoring Modalities on the Horizon: Detection and Management of Acute Brain Injury in Children.Neurocritical care · 2023Review
- The Effect of Electroencephalography Abnormalities on Cerebral Autoregulation in Sedated Ventilated Children.Pediatric reports · 2022Article
- Article
- Making Waves: Will It Help Children with Traumatic Brain Injury?Neurocritical care · 2021Article
- Protective Effects of Aquaporin-4 Deficiency on Longer-term Neurological Outcomes in a Mouse Model.Neurochemical research · 2021Article
- Inhibition of RNF6 alleviates traumatic brain injury by suppressing STAT3 signaling in rats.Brain and behavior · 2020Article
- Pharmacologic Control of Blood Pressure in Infants and Children.Pediatric cardiology · 2020Review
- Transcranial Doppler as a non-invasive method to estimate cerebral perfusion pressure in children with severe traumatic brain injury.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Addressing Key Clinical Care and Clinical Research Needs in Severe Pediatric Traumatic Brain Injury: Perspectives From a Focused International Conference.Frontiers in pediatrics · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildren who survive acute traumatic brain injury are at risk of death from subsequent brain swelling and secondary injury. Strict physiologic management in the ICU after traumatic brain injury is believed to be key to survival, and cerebral perfusion pressure is a prominent aspect of post brain injury care. However, optimal cerebral perfusion pressure targets for children are not known. Autoregulation monitoring has been used to delineate individualized optimal perfusion pressures for patients with traumatic brain injury. The methods to do so are diverse, confusing, and not universally validated.
methodsIn this manuscript, we discuss the history of autoregulation monitoring, outline and categorize the methods used to measure autoregulation, and review the available validation data for methods used to monitor autoregulation.
conclusionsImpaired autoregulation after traumatic brain injury is associated with a poor prognosis. Observational data suggests that optimal neurologic outcome and survival are associated with optimal perfusion pressure defined by autoregulation monitoring. No randomized, controlled, interventional data is available to assess autoregulation monitoring after pediatric traumatic brain injury.
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