ArticleBritish journal of cancer2018
Treponema denticola chymotrypsin-like proteinase may contribute to orodigestive carcinogenesis through immunomodulation.
Article in British journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 3 of them syntheses that pooled it.
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Who cites it
74 citing papers in PubMed, 3 syntheses or guidelines pooled it, 117 citations in OpenAlex.
- Gingipain inhibitors as an innovative therapy for periodontal and associated-systemic diseases: a systematic review.Clinical oral investigations · 2025Pooled it
- The effect of periodontal bacteria infection on incidence and prognosis of cancer: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Potential risk of certain cancers among patients with Periodontitis: a supplementary meta-analysis of a large-scale population.International journal of medical sciences · 2020Pooled it
- Bacterial proteases and Bcl-2 proteins in peri-implant tissues: An exploratory cross-sectional study.Clinical oral investigations · 2026Article
- Intratumoral microbiota in cancer: molecular mechanism and therapeutic strategies.Molecular biomedicine · 2026Review
- MGM as a Large-Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Differences in the Oral Microbiome Between Patients With and Without Oral Squamous Cell Carcinoma.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2026Article
- Article
- Proteomics of Periodontitis-Associated Bacteria and Its Link to Oral Squamous Cell Carcinoma: A Contemporaneous Review.International dental journal · 2026Review
- Lesion-specific oral microbiome signatures and predicted carcinogenic pathways in oral squamous cell carcinoma: a paired-site study in Pakistan.Journal of oral microbiology · 2026Article
- Red-complex bacteria: immunological background leading to the development of head and neck cancers.Frontiers in immunology · 2026Review
- Could periodontitis be associated with overall and cancer-specific mortality risk; a 35-year Swedish cohort study.Acta odontologica Scandinavica · 2025Article
- Tissue-resident microbiota impacts colorectal cancer progression and prognosis.Nature communications · 2025Article
- Oral Microbiota and Carcinogenesis: Exploring the Systemic Impact of Oral Pathogens.Pathogens (Basel, Switzerland) · 2025Review
- The potential role of genus Treponema in carcinogenesis with a focus on oral squamous cell carcinoma: a scoping review of the evidence.BMC oral health · 2025Article
- Red Complex Periodontal Pathogens and Their Potential Role in Colorectal Carcinogenesis: A Narrative Review.International journal of molecular sciences · 2025Review
- Caries status influence GCF MMP-9 in association with serum vitamin D: an exploratory retrospective cross-sectional study.BMC oral health · 2025Article
- Periodontal Pathobionts and Respiratory Diseases: Mechanisms of Interaction and Implications for Interdisciplinary Care.Biomedicines · 2025Review
- Causal Association Between Microbiome and Oral-Oropharyngeal Cancer: A Mendelian Randomization Study.International dental journal · 2025Article
- Assessment of periodontitis vaccine using three different bacterial outer membrane vesicles in canine model.mSphere · 2025Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriodontal pathogens have been linked to oral and gastrointestinal (orodigestive) carcinogenesis. However, the exact mechanisms remain unknown. Treponema denticola (Td) is associated with severe periodontitis, a chronic inflammatory disease leading to tooth loss. The anaerobic spirochete Td is an invasive bacteria due to its major virulence factor chymotrypsin-like proteinase. Here we aimed to investigate the presence of Td chymotrypsin-like proteinase (Td-CTLP) in major orodigestive tumours and to elucidate potential mechanisms for Td to contribute to carcinogenesis.
methodsThe presence of Td-CTLP within orodigestive tumour tissues was examined using immunohistochemistry. Oral, tonsillar, and oesophageal squamous cell carcinomas, alongside gastric, pancreatic, and colon adenocarcinomas were stained with a Td-CTLP-specific antibody. Gingival tissue from periodontitis patients served as positive controls. SDS-PAGE and immunoblot were used to analyse the immumodulatory activity of Td-CTLP in vitro.
resultsTd-CTLP was present in majority of orodigestive tumour samples. Td-CTLP was found to convert pro MMP-8 and -9 into their active forms. In addition, Td-CTLP was able to degrade the proteinase inhibitors TIMP-1, TIMP-2, and α-1-antichymotrypsin, as well as complement C1q.
conclusionsBecause of its presence within tumours and regulatory activity on proteins critical for the regulation of tumour microenvironment and inflammation, the Td-CTLP may contribute to orodigestive carcinogenesis.
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