ArticleMedical physics2018
Robust optimization in IMPT using quadratic objective functions to account for the minimum MU constraint.
Article in Medical physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- AI in Proton Therapy Treatment Planning: A Narrative Review.International journal of particle therapy · 2026Article
- [Molecular Mechanism of microRNA-429 TargetingSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Article
- Noisy probing dose facilitated dose prediction for pencil beam scanning proton therapy: Physics enhances generalizability.Medical physics · 2026Article
- Article
- Diffusion Transformer-based Universal Dose Denoising for Pencil Beam Scanning Proton Therapy.ArXiv · 2025Article
- Direct minimization of normal-tissue toxicity via an NTCP-based IMPT planning method.Medical physics · 2025Article
- Enabling clinical use of linear energy transfer in proton therapy for head and neck cancer - A review of implications for treatment planning and adverse events study.Visualized cancer medicine · 2025Article
- Accurate patient alignment without unnecessary imaging using patient-specific 3D CT images synthesized from 2D kV images.Communications medicine · 2024Article
- Proton ARC based LATTICE radiation therapy: feasibility study, energy layer optimization and LET optimization.Physics in medicine and biology · 2024Article
- TEAM: Triangular-mEsh Adaptive and Multiscale proton spot generation method.Medical physics · 2024Article
- [miR-2110 Affects the Biological Behaviors of Lung Adenocarcinoma by Regulating CDT1].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- Optimal minimum MU for intensity-modulated proton therapy with pencil-beam scanning proton beams.Journal of applied clinical medical physics · 2024Article
- Simultaneous dose and dose rate optimization via dose modifying factor modeling for FLASH effective dose.Medical physics · 2024Article
- NRG Oncology and Particle Therapy Co-Operative Group Patterns of Practice Survey and Consensus Recommendations on Pencil-Beam Scanning Proton Stereotactic Body Radiation Therapy and Hypofractionated Radiation Therapy for Thoracic Malignancies.International journal of radiation oncology, biology, physics · 2024Review
- Biological optimization for hybrid proton-photon radiotherapy.Physics in medicine and biology · 2024Article
- Article
- Optimizing linear energy transfer distribution in intensity-modulated proton therapy using the alternating direction method of multipliers.Frontiers in oncology · 2024Article
- Lattice position optimization for LATTICE therapy.Medical physics · 2023Article
- Deep-learning based fast and accurate 3D CT deformable image registration in lung cancer.Medical physics · 2023Article
- An orthogonal matching pursuit optimization method for solving minimum-monitor-unit problems: Applications to proton IMPT, ARC and FLASH.Medical physics · 2023Article
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Authors and funding
5 authors.
Funding
Abstract
purposeCurrently, in clinical practice of intensity-modulated proton therapy (IMPT), the influence of the minimum monitor unit (MU) constraint is taken into account through postprocessing after the optimization is completed. This may degrade the plan quality and plan robustness. This study aims to mitigate the impact of the minimum MU constraint directly during the plan robust optimization. METHODS AND MATERIALS: Cao et al. have demonstrated a two-stage method to account for the minimum MU constraint using linear programming without the impact of uncertainties considered. In this study, we took the minimum MU constraint into consideration using quadratic optimization and simultaneously had the impact of uncertainties considered using robust optimization. We evaluated our method using seven cancer patients with different machine settings.
resultThe new method achieved better plan quality than the conventional method. The D
conclusionOur new method of incorporating the minimum MU constraint directly into the plan robust optimization can produce machine-deliverable plans with better tumor coverage while maintaining high-plan robustness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.