ArticleEmerging infectious diseases2017
Outbreaks of Neuroinvasive Astrovirus Associated with Encephalomyelitis, Weakness, and Paralysis among Weaned Pigs, Hungary.
Article in Emerging infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 89 citations in OpenAlex.
- Virome of post-weaned diarrhoeic pigs and healthy cohorts in England.Virology journal · 2026Article
- Porcine astrovirus: a review.Archives of virology · 2026Review
- Article
- Isolation and identification of a new porcine astrovirus 5 demonstrated that oxidative stress enhances porcine astrovirus replication.BMC veterinary research · 2025Article
- Novel murine model of human astrovirus infection reveals cardiovascular tropismJournal of virology · 2025Article
- Isolation and preliminary pathogenicity of a recent feline astrovirus strain in China.Frontiers in veterinary science · 2025Article
- Prevalence, Genetics, and Evolution of Porcine Astrovirus 3 in China.Transboundary and emerging diseases · 2025Article
- Complexity of Diarrhea-Associated Viruses in Stunted Pigs Identified by Viral Metagenomics.Transboundary and emerging diseases · 2025Article
- Porcine Astrovirus Infection in Brains of Pigs in Korea.Viruses · 2024Article
- Astrovirus induced nonpurulent encephalomyelitis in sheep: First report from Türkiye by high-throughput sequencing.Veterinary medicine and science · 2024Article
- Structure and antigenicity of the divergent human astrovirus VA1 capsid spike.PLoS pathogens · 2024Article
- Prevalence Estimation and Genetic Characterization of Porcine Parainfluenza Virus 1 (PPIV-1) in Hungary and the First Report of the Virus in Slovakia.Transboundary and emerging diseases · 2024Article
- Coinfection of porcine astrovirus and other porcine viruses in diarrheic pigs in Haryana, India.Archives of virology · 2023Article
- Pathogenesis and outcome of VA1 astrovirus infection in the human brain are defined by disruption of neural functions and imbalanced host immune responses.PLoS pathogens · 2023Article
- Article
- Molecular Detection and Genetic Characterization of Potential Zoonotic Swine Enteric Viruses in Northern China.Pathogens (Basel, Switzerland) · 2022Article
- Article
- Epidemiology of Astrovirus, Norovirus and Sapovirus in Greek pig farms indicates high prevalence of Mamastrovirus suggesting the potential need for systematic surveillance.Porcine health management · 2022Article
- Identification of a Novel Astrovirus in Pinnipeds.Frontiers in microbiology · 2022Article
- Dynamics of the Enteric Virome in a Swine Herd Affected by Non-PCV2/PRRSV Postweaning Wasting Syndrome.Viruses · 2021Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A large, highly prolific swine farm in Hungary had a 2-year history of neurologic disease among newly weaned (25- to 35-day-old) pigs, with clinical signs of posterior paraplegia and a high mortality rate. Affected pigs that were necropsied had encephalomyelitis and neural necrosis. Porcine astrovirus type 3 was identified by reverse transcription PCR and in situ hybridization in brain and spinal cord samples in 6 animals from this farm. Among tissues tested by quantitative RT-PCR, the highest viral loads were detected in brain stem and spinal cord. Similar porcine astrovirus type 3 was also detected in archived brain and spinal cord samples from another 2 geographically distant farms. Viral RNA was predominantly restricted to neurons, particularly in the brain stem, cerebellum (Purkinje cells), and cervical spinal cord. Astrovirus was generally undetectable in feces but present in respiratory samples, indicating a possible respiratory infection. Astrovirus could cause common, neuroinvasive epidemic disease.
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