ArticleEmerging infectious diseases2017
High Rate of MCR-1-Producing Escherichia coli and Klebsiella pneumoniae among Pigs, Portugal.
Article in Emerging infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 78 citations in OpenAlex.
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- Peptide MSI-1 inhibited MCR-1 and regulated outer membrane vesicles to combat immune evasion of Escherichia coli.Microbial biotechnology · 2023Article
- Exploring the epidemiology of mcr genes, genetic context and plasmids in Enterobacteriaceae originating from pigs and humans on farms in Thailand.The Journal of antimicrobial chemotherapy · 2023Article
- First Known Report ofInternational journal of environmental research and public health · 2023Article
- The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2020/2021.EFSA journal. European Food Safety Authority · 2023Article
- Epidemiology and zoonotic transmission ofFrontiers in microbiology · 2023Article
- Report and Comparative Genomics of an NDM-5-ProducingMicroorganisms · 2022Article
- Highly Sensitive and Specific Detection of Mobilized Colistin Resistance GeneMicrobiology spectrum · 2022Article
- Occurrence and Biological Cost ofAntibiotics (Basel, Switzerland) · 2022Article
- Longitudinal Study Detects the Co-Carriage of ESBL andAnimals : an open access journal from MDPI · 2022Article
- Worldwide Prevalence ofPathogens (Basel, Switzerland) · 2022Review
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- The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2019-2020.EFSA journal. European Food Safety Authority · 2022Article
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- Prevalence of Colistin-Resistant Bacteria among Retail Meats in Japan.Food safety (Tokyo, Japan) · 2021Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mcr-1 (mobile colistin resistance 1) gene, which encodes phosphoethanolamine transferase, has been recently identified as a source of acquired resistance to polymyxins in Escherichia coli. Using the SuperPolymyxin selective medium, we prospectively screened 100 pigs at 2 farms in Portugal for polymyxin-resistant Enterobacteriaceae and recovered 98 plasmid-mediated MCR-1-producing isolates. Most isolates corresponded to nonclonally related E. coli belonging to many sequence types; we also found 2 Klebsiella pneumoniae sequence types. The mcr-1 gene was carried on IncHI2 or IncP plasmid backbones. Our finding of a high rate of MCR-1 producers on 2 pig farms in Portugal highlights the diffusion of that colistin-resistance determinant at the farm level. The fact that the pigs received colistin as metaphylaxis in their feed during the 6 weeks before sampling suggests selective pressure.
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