ArticleJournal of enzyme inhibition and medicinal chemistry2018
Synthesis, physiochemical property and antimicrobial activity of novel quaternary ammonium salts.
Article in Journal of enzyme inhibition and medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Ammonium Catecholaldehydes as Multifunctional Bioactive Agents: Evaluating Antimicrobial, Antioxidant, and Antiplatelet Activity.International journal of molecular sciences · 2025Article
- Fabrication and Application of Tannin Double Quaternary Ammonium Salt/Polyvinyl Alcohol as Efficient Sterilization and Preservation Material for Food Packaging.Molecules (Basel, Switzerland) · 2024Article
- Advances in the Synthesis of Biologically Active Quaternary Ammonium Compounds.International journal of molecular sciences · 2024Review
- Review
- Efficacy of Novel Quaternary Ammonium and Phosphonium Salts Differing in Cation Type and Alkyl Chain Length against Antibiotic-ResistantInternational journal of molecular sciences · 2023Article
- Cytotoxicity and Antibacterial Efficacy of Betaine- and Choline-Substituted Polymers.ACS applied polymer materials · 2023Article
- The effectiveness of newly synthesized quaternary ammonium salts differing in chain length and type of counterion against priority human pathogens.Scientific reports · 2022Article
- Antiviral capacity of polypropylene/(1-Hexadecyl) trimethyl-ammonium bromide composites against COVID-19.Polymer engineering and science · 2022Article
- Quaternary Phosphonium Compounds: An Examination of Non-Nitrogenous Cationic Amphiphiles That Evade Disinfectant Resistance.ACS infectious diseases · 2022Article
- Synthesis and Antimicrobial Evaluation of Bis-morpholine Triazine Quaternary Ammonium Salts.ChemMedChem · 2021Article
- Study of Ground State Interactions of Enantiopure Chiral Quaternary Ammonium Salts and Amides, Nitroalkanes, Nitroalkenes, Esters, Heterocycles, Ketones and Fluoroamides.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives.International journal of molecular sciences · 2021Review
- Quaternary Ammonium Compounds (QACs) and Ionic Liquids (ILs) as Biocides: From Simple Antiseptics to Tunable Antimicrobials.International journal of molecular sciences · 2021Review
- Metallocene QACs: The Incorporation of Ferrocene Moieties into monoQAC and bisQAC Structures.ChemMedChem · 2021Article
- Diversity-oriented synthesis and antifungal activities of novel pimprinine derivative bearing a 1,3,4-oxadiazole-5-thioether moiety.Molecular diversity · 2021Article
- Advancements in the Development of Non-Nitrogen-Based Amphiphilic Antiseptics to Overcome Pathogenic Bacterial Resistance.ChemMedChem · 2020Review
- Further Investigations into Rigidity-Activity Relationships in BisQAC Amphiphilic Antiseptics.ChemMedChem · 2020Article
- Evaluation of Antibacterial Activity of Three Quaternary Ammonium Disinfectants on Different Germs Isolated from the Hospital Environment.BioMed research international · 2020Article
- Ionic liquids strongly affect the interaction of bacteria with magnesium oxide and silica nanoparticles.RSC advances · 2019Article
- Antibacterial performance of polymer quaternary ammonium salt-capped silver nanoparticles onRSC advances · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Twenty-four novel 5-phenyl-1,3,4-oxadiazole-2-thiol (POT) analogues, benzo[d]oxazole-2-thiol, benzo[d]thiazole-2-thiol and 5-methyl-1,3,4-thiadiazole-2-thiol-substituted N,N-bis(2-hydroxyethyl) quaternary ammonium salts (QAS) (5a-d, 6a-d, 7a-d, 10a-d, 13a-d, 16a-d) were prepared and characterised by FTIR, NMR and elemental analysis. Part of target compounds (5d, 6d, 7d, 10d, 13d, 16d) displayed potent antimicrobial effect against ten common pathogens (S. aureus, α-H-tococcus, β-H-tococcus, E. coli, P. aeruginosa, Proteus vulgaris, Canidia Albicans, Cytospora mandshurica, Physalospora piricola, Aspergillus niger) and had relatively low cytotoxity against two human cell lines (HaCat and LO2). TEM and SEM images of E. coli and S. aureus morphologies treated with 7d showed that the antibacterial mechanism might be the QAS fixing on cell wall surfaces and puncturing to result in the release of bacterial cytoplasm. This study provides new information of QAS, which could be used to design novel antimicrobial agents applied in clinic or agriculture.
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Registered trials
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