ArticleJournal of magnetic resonance imaging : JMRI2018
Mapping brown adipose tissue based on fat water fraction provided by Z-spectral imaging.
Article in Journal of magnetic resonance imaging : JMRI, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets.MedComm · 2026Review
- Single-Cell Metabolic Imaging and Digital Scoring of Fat Tissue Remodeling by Label-Free Metabolic Microscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- MR-based fat fraction changes in subcutaneous adipose tissue in people with obesity undergoing a weight loss intervention: results from the LION study.Quantitative imaging in medicine and surgery · 2025Article
- Z-Spectral MRI Quantifies the Mass and Metabolic Activity of Adipose Tissues With Fat-Water-Fraction and Amide-Proton-Transfer Contrasts.Journal of magnetic resonance imaging : JMRI · 2025Article
- Imaging Brown Adipose Tissue: Current State and Future Perspective.Theranostics · 2025Review
- Development and Validation of Four Different Methods to Improve MRI-CEST Tumor pH Mapping in Presence of Fat.Journal of imaging · 2024Article
- Non-invasive mapping of brown adipose tissue activity with magnetic resonance imaging.Nature metabolism · 2024Article
- Analytical solution of the Bloch-McConnell equations for steady-state CEST Z-spectra.Magnetic resonance imaging · 2024Article
- Phase-independent thermometry by Z-spectrum MR imaging.Magnetic resonance in medicine · 2022Article
- Molecular Imaging of Brown Adipose Tissue Mass.International journal of molecular sciences · 2021Review
- [Comparison ofNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- Characterization of brown adipose tissue (BAT) in polycystic ovary syndrome (PCOS) patients by Z-Spectral Imaging (ZSI).European journal of radiology · 2020Article
- Magnetic Resonance Imaging Techniques for Brown Adipose Tissue Detection.Frontiers in endocrinology · 2020Review
- Non-invasive Imaging Methods for Brown Adipose Tissue Detection and Function Evaluation.Internal medicine: open access · 2018Article
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6 authors.
Funding
Abstract
backgroundBrown adipose tissue (BAT) has a great relevance in metabolic diseases and has been shown to be reduced in obesity and insulin resistance patients. Currently, Dixon MRI is used to calculate fat-water fraction (FWF) and differentiate BAT from white adipose tissue (WAT). However, it may fail in areas of phase wrapping and introduce fat-water swapping artifacts. PURPOSE: To investigate the capacity of the Z-spectrum imaging (ZSI) for the identification of BAT in vivo. STUDY TYPE: Retrospective study. SPECIMENS: WAT, BAT, and lean tissue from healthy mice. ANIMALS: Four C57BL/6 healthy mice. POPULATION: Five healthy volunteers. FIELD STRENGTH: 9.4T, 3T for volunteers. SEQUENCE: Z-Spectra data were fitted to a model with three Lorentzian peaks reflecting the direct saturation of tissue water (W) and methylene fat (F), and the magnetization transfer from the semi-solid tissues. The peak amplitudes of water and fat were used to map the FWF. The novel FWF metric was calibrated with an oil and water mixture phantom and validated in specimens, mice and human subjects. ASSESSMEMT: FWF distribution was compared with published works and values compared with Dixon's MRI results. STATISTICAL TESTS: Comparisons were performed by t-tests.
resultsZSI clearly differentiated WAT, BAT, and lean tissues by having FWF = 1, 0.5, and 0, respectively. Calibration with oil mixture phantoms revealed a linear relationship between FWF and the actual fat fraction (R DATA
conclusionZSI can derive artifact-free FWF maps, which can be used to identify BAT distribution in vivo noninvasively. LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:1527-1533.
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