ArticleIndian journal of pediatrics2018
Association of IL-10 Gene Polymorphism (-819C > T, -592C > A and -1082G > A) with Preterm Birth.
Article in Indian journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Association of IL-4 and IL-10 Polymorphisms With Preterm Birth Susceptibility: A Systematic Review and Meta-Analysis.Frontiers in immunology · 2022Pooled it
- A Scoping Review of Preterm Birth Risk Factors.American journal of perinatology · 2024Article
- Role ofJournal of clinical medicine · 2024Article
- The Role of Genetics in Preterm Birth.Reproductive sciences (Thousand Oaks, Calif.) · 2023Review
- Blood gene transcript signature profiling in pregnancies resulting in preterm birth: A systematic review.European journal of obstetrics & gynecology and reproductive biology: X · 2020Review
- Regulatory B Cells Are Decreased and Impaired in Their Function in Peripheral Maternal Blood in Pre-term Birth.Frontiers in immunology · 2020Article
- Role ofJournal of genetics · 2020Article
- Genetic Polymorphism and Preterm Birth.Indian journal of pediatrics · 2018Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo analyze the association of IL-10 gene and its polymorphisms with preterm birth (PTB).
methodsFive hundred and fifty nine women with term birth and 559 with preterm birth were recruited from Lucknow, India. Genetic association analysis was conducted between cases and controls. Subjects recruited as cases were women (aged between 18-40 y) with singleton delivery before 37 wk of gestation and controls were with delivery after or on 37 wk. The genotyping was performed for rs1800871, rs1800872 and rs1800896 for assessing the allelic distribution, haplotypic association and linkage disequilibrium analysis. IL-10mRNA levels were evaluated by real time quantitative polymerase chain reaction (PCR) method.
resultsThe risk of PTB was found significant in women carrying IL-10 (-1082) GA genotype [OR=1.72(1.7-2.5), p=0.006]. The haplotypic analysis of studied polymorphisms for rs1800871, rs1800872 and rs1800896 depicted the association of ATA (p=0.02) and ATC (p=0.01) haplotypes with PTB. The IL-10 mRNA levels were significantly lower in cases (p=0.05).
conclusionsIL-10 marks a protective impact in the inflammatory pathway of PTB.
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