ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2018
A preliminary prediction model for potentially guiding patient choices between breast conserving surgery and mastectomy in early breast cancer patients; a Dutch experience.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Computational Modeling of Patient-Specific Healing and Deformation Outcomes Following Breast-Conserving Surgery Based on MRI Data.Annals of biomedical engineering · 2026Article
- Computational mechanobiology model evaluating healing of postoperative cavities following breast-conserving surgery.Computers in biology and medicine · 2023Article
- Computational Mechanobiology Model Evaluating Healing of Postoperative Cavities Following Breast-Conserving Surgery.bioRxiv : the preprint server for biology · 2023Article
- Regenerative tissue filler for breast conserving surgery and other soft tissue restoration and reconstruction needs.Scientific reports · 2021Article
- MRI-Derived Tumour-to-Breast Volume Is Associated with the Extent of Breast Surgery.Diagnostics (Basel, Switzerland) · 2021Article
- An absence of equipoise: Examining surgeons' decision talk during encounters with women considering breast cancer surgery.PloS one · 2021Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo guide early stage breast cancer patients to choose between breast conserving surgery (BCS) and mastectomy (MST) considering the predicted cosmetic result and quality of life (QoL).
methodsA decision model was built to compare QoL after BCS and MST. Treatment could result in BCS with good cosmesis, BCS with poor cosmesis, MST only, and MST with breast reconstruction. QoL for these treatment outcomes were obtained from a previous study and the literature and translated into EuroQoL-5D derived utilities. Chance of good cosmesis after BCS was predicted based on tumor location and tumor/breast volume ratio. The decision model determined whether the expected QoL was superior after BCS or MST based on chance of good cosmesis.
resultsThe mean utility for the treatments such as BCS with good cosmesis, BCS with poor cosmesis, MST only, and MST with breast reconstruction were 0.908, 0.843, 0.859, and 0.876, respectively. BCS resulted in superior QoL compared to MST in patients with a chance of good cosmesis above 36%. This 36% threshold is reached in case the tumor is located in the upper lateral, lower lateral, upper medial, lower medial, and central quadrant of the breast with a tumor/breast volume ratio below 21.6, 4.1, 15.1, 3.2, and 14.7, respectively.
conclusionsBCS results in superior QoL in patients with tumors in the upper breast quadrants or centrally and a tumor/breast volume ratio below 15. MST results in superior QoL in patients with tumors in the lower breast quadrants and a tumor/breast volume ratio above 4.
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