Evidence map›Paper›PMID 29147878›Full record

ArticleDigestive diseases and sciences2018

Knowledge Gaps in the Management of Postoperative Crohn's Disease: A US National Survey.

Vu Q Nguyen, Jessica L Mays, Marissa Lang, Yingxing Wu, Themistocles Dassopoulos, Miguel Regueiro, Alan Moss, Deborah D Proctor, Dario Sorrentino

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Vu Q NguyenIBD Center, Division of Gastroenterology, Virginia Tech Carilion School of Medicine, 3 Riverside Circle, 3rd Floor Gastroenterology, Roanoke, VA, 24016, USA.
Jessica L MaysIBD Center, Division of Gastroenterology, Virginia Tech Carilion School of Medicine, 3 Riverside Circle, 3rd Floor Gastroenterology, Roanoke, VA, 24016, USA.
Marissa LangIBD Center, Division of Gastroenterology, Virginia Tech Carilion School of Medicine, 3 Riverside Circle, 3rd Floor Gastroenterology, Roanoke, VA, 24016, USA.
Yingxing WuIBD Center, Division of Gastroenterology, Virginia Tech Carilion School of Medicine, 3 Riverside Circle, 3rd Floor Gastroenterology, Roanoke, VA, 24016, USA.
Themistocles DassopoulosIBD Center, Division of Gastroenterology, Baylor Medical Center, Dallas, TX, USA.
Miguel RegueiroDivision of Gastroenterology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Alan MossDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Deborah D ProctorDivision of Gastroenterology, Yale University School of Medicine, New Haven, CT, USA.
Dario SorrentinoIBD Center, Division of Gastroenterology, Virginia Tech Carilion School of Medicine, 3 Riverside Circle, 3rd Floor Gastroenterology, Roanoke, VA, 24016, USA. drsorrentino@carilionclinic.org.
Carilion Clinic · USBaylor University Medical Center · USBeth Israel Deaconess Medical Center · USUniversity of Pittsburgh Medical Center · USUniversity of Udine · ITVirginia Tech · USYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative recurrence (POR) of Crohn's disease (CD) is common. Guidelines on POR management have recently been issued, but clinical practice may vary.

aimsTo examine the current clinical practice of POR management in the USA

methodsA web-based survey was sent to all members of the American Gastroenterological Association and the American College of Gastroenterology. The survey consisted of multiple-choice questions with clinical scenarios to assess how participants manage POR.

resultsA total of 189 responses were received from practices in 34 states. 44% of participants were from academic settings. The median number of CD patients seen each month was 20-30 patients per participant. The majority of participants considered smoking, prior intestinal surgery, penetrating disease, perianal fistula, early disease onset, and long extent of disease as high-risk factors for POR. To diagnose and grade endoscopic recurrence, 57% of participants used an endoscopic scoring system; 86% defined clinical recurrence using a combination of symptoms and endoscopic findings; and 79% of participants routinely performed colonoscopy after surgery. In high-risk patients, 65% offered medical prophylaxis-most often biologics and/or immunomodulators-immediately after surgery, while 34% offered medical prophylaxis regardless of the patient's risk of POR. 64% of participants never stopped medical prophylaxis once initiated.

conclusionsMost gastroenterologists routinely perform colonoscopy to guide POR management. The majority of these providers continue medical prophylaxis indefinitely regardless of subsequent endoscopic findings. Further research is needed to determine the risks and benefits of continuing versus deescalating therapy in patients with potentially surgically induced remission.

Indexed as

AdultCrohn DiseaseData CollectionGastroenterologistsHumansMiddle AgedPostoperative ComplicationsRecurrenceRisk FactorsUnited StatesCrohn’s diseaseInflammatory bowel diseaseMedical prophylaxisPostoperative relapseRisk factorsSurgery

Identifiers

PMID29147878
OpenAlexW2769377409

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.