ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2018
Radiotherapy for extramedullary leukaemic manifestation (Chloroma).
Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Clinical and Molecular Characterization of Myeloid Sarcoma: A Systematic Review and Meta-Analysis.Cancers · 2025Review
- Radiotherapy for Isolated Breast Myeloid Sarcoma.Journal of medical cases · 2025Article
- Article
- Ulcerating skin lesions from blastic plasmacytoid dendritic cell neoplasm responding to low-dose radiotherapy-a case report and literature review.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2024Review
- A case of relapsed acute myeloid leukemia mimicking acute otomastoiditis.Clinical case reports · 2024Article
- Brachytherapy for uterine cervix-limited acute myeloid leukemia relapse.Journal of contemporary brachytherapy · 2022Article
- Incidence, clinical characteristics, and prognostic nomograms for patients with myeloid sarcoma: A SEER-based study.Frontiers in oncology · 2022Article
- Extramedullary hematopoiesis causing spinal cord compression with excellent durable response after radiation therapy: Case report and review of the literature.Journal of family medicine and primary care · 2020Article
- Maximizing the Clinical Benefit of Radiotherapy in Solitary Plasmacytoma: An International Multicenter Analysis.Cancers · 2020Article
- Impact of radiation dose on local control and survival in extramedullary head and neck plasmacytoma.Radiation oncology (London, England) · 2019Article
- Unilateral Proptosis As An Initial Sign Of Acute Myeloid Leukemia In A Child: A Case Report.International medical case reports journal · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeExtramedullary leukaemic disease (EMD, synonym chloroma) is a rare solid manifestation of myeloid leukaemia for which the value of radiotherapy (RT) as a treatment strategy remains controversial. The aim of this study is to analyse the effectiveness of various RT doses for EMD in the modern treatment era. MATERIALS AND
methodsBetween January 2000 and June 2016, 20 patients with total of 45 lesions underwent RT for EMD at our institution.
resultsWith a median radiation dose of 26 Gy (range 4-42 Gy), local remission could be achieved in 91% of patients (complete remission rate: 71%). The median duration of local control (DOLC) was 17 months (95% confidence interval [CI] 0.5-33) and the median overall survival (OS) after chloroma onset was 24 months (95% CI 11-38). No noticeable difference between high- and low-dose regimens has been observed (74% versus 68%; P = 0.5). In the multivariate analysis, only Eastern Cooperative Oncology Group (ECOG) score and bone marrow state during RT have proven to be determinant for durable local control and OS.
conclusionsLow-dose RT (≤26 Gy) achieves good local control compared to high-dose regimes. Bone marrow state during RT and ECOG score during RT may play a crucial role, influencing both DOLC and OS.
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