Evidence map›Paper›PMID 29147682›Full record

ArticleACS biomaterials science & engineering2017

Synthesis and Application of Injectable Bioorthogonal Dendrimer Hydrogels for Local Drug Delivery.

Leyuan Xu, Remy C Cooper, Juan Wang, W Andrew Yeudall, Hu Yang

Abstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Electrically conductive "SMART" hydrogels for on-demand drug delivery.Asian journal of pharmaceutical sciences · 2025
    Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Nanocarrier-hydrogel composite delivery systems for precision drug release.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2022
    Review
  10. Review
  11. Review
  12. Article
  13. Review
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  16. Article
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  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Leyuan XuDepartment of Chemical and Life Science Engineering, Virginia Commonwealth University, 737 North 5 Street, Richmond, Virginia 23219, United States.
Remy C CooperDepartment of Biomedical Engineering, 601 West Main Street, Virginia Commonwealth University, Richmond, Virginia 23284, United States.
Juan WangDepartment of Chemical and Life Science Engineering, Virginia Commonwealth University, 737 North 5 Street, Richmond, Virginia 23219, United States.
W Andrew YeudallDepartment of Oral Biology, Augusta University, 1120 15 Street, Augusta, Georgia 30912, United States.
Hu YangDepartment of Chemical and Life Science Engineering, Virginia Commonwealth University, 737 North 5 Street, Richmond, Virginia 23219, United States.

Funding

EPS8 as a Driver of the Oral Cancer Initiating Cell Phenotype.R01DE024381 · NIDCR · VIRGINIA COMMONWEALTH UNIVERSITY · PI YEUDALL, WILLIAM ANDREW · 2014 to 2017
$1.3M
Hybrid Nanoparticles for GlaucomaR01EY024072 · NEI · VIRGINIA COMMONWEALTH UNIVERSITY · PI KOMPELLA, UDAY B, YANG, HU · 2014 to 2016
$1.3M
NEI NIH HHS R01 EY024072NIDCR NIH HHS R01 DE024381
6 · The paper itself

Abstract

We developed novel dendrimer hydrogels (DH)s on the basis of bioorthogonal chemistry, in which polyamidoamine (PAMAM) dendrimer generation 4.0 (G4) functionalized with strained alkyne dibenzocyclooctyne (DBCO) via PEG spacer (M

Indexed as

chemotherapycopper-free click chemistryhydrogellocal drug deliverynanomedicine

Identifiers

PMID29147682
PMCPMC5683721

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.