ArticleACS biomaterials science & engineering2017
Crimped Nanofibrous Biomaterials Mimic Microstructure and Mechanics of Native Tissue and Alter Strain Transfer to Cells.
Article in ACS biomaterials science & engineering, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed.
- Nanofiber based transformative approaches for tendon regenerative engineering: past, present and future.Nanomedicine (London, England) · 2026Review
- Hierarchy Reproduction: Multiphasic Strategies for Tendon/Ligament-Bone Junction Repair.Biomaterials research · 2025Review
- Augmentation of Tendon and Ligament Repair with Fiber-Reinforced Hydrogel Composites.Advanced healthcare materials · 2024Review
- Intermittent cyclic stretch of engineered ligaments drives hierarchical collagen fiber maturation in a dose- and organizational-dependent manner.Acta biomaterialia · 2024Article
- Mechanical strategies to promote vascularization for tissue engineering and regenerative medicine.Burns & trauma · 2024Review
- Multi-material electrospinning: from methods to biomedical applications.Materials today. Bio · 2023Review
- Mimicking the Graded Wavy Structure of the Anterior Cruciate Ligament.Advanced healthcare materials · 2023Article
- Mechanoepigenetic regulation of extracellular matrix homeostasis via Yap and Taz.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Recent Advances in Tissue-Engineered Cardiac Scaffolds-The Progress and Gap in Mimicking Native Myocardium Mechanical Behaviors.Journal of functional biomaterials · 2023Review
- Mouse Achilles tendons exhibit collagen disorganization but minimal collagen denaturation during cyclic loading to failure.Journal of biomechanics · 2023Article
- Challenges of Periodontal Tissue Engineering: Increasing Biomimicry through 3D Printing and Controlled Dynamic Environment.Nanomaterials (Basel, Switzerland) · 2022Review
- Crimped nanofiber scaffold mimicking tendon-to-bone interface for fatty-infiltrated massive rotator cuff repair.Bioactive materials · 2022Article
- Electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) scaffolds - a step towards ligament repair applications.Science and technology of advanced materials · 2022Article
- 3D-Printed Collagen-Based Waveform Microfibrous Scaffold for Periodontal Ligament Reconstruction.International journal of molecular sciences · 2021Article
- Electrospun hydrogels for dynamic culture systems: advantages, progress, and opportunities.Biomaterials science · 2021Review
- Boost Tendon/Ligament Repair With Biomimetic and Smart Cellular Constructs.Frontiers in bioengineering and biotechnology · 2021Review
- Three-dimensional computation of fibre orientation, diameter and branching in segmented image stacks of fibrous networks.Journal of the Royal Society, Interface · 2020Article
- Cellular sensing of micron-scale curvature: a frontier in understanding the microenvironment.Open biology · 2019Review
- From fiber curls to mesh waves: a platform for the fabrication of hierarchically structured nanofibers mimicking natural tissue formation.Nanoscale · 2019Article
- Mechanical and Microstructural Properties of Native Pediatric Posterior Cruciate and Collateral Ligaments.Orthopaedic journal of sports medicine · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
To fully recapitulate tissue microstructure and mechanics, fiber crimping must exist within biomaterials used for tendon/ligament engineering. Existing crimped nanofibrous scaffolds produced via electrospinning are dense materials that prevent cellular infiltration into the scaffold interior. In this study, we used a sacrificial fiber population to increase the scaffold porosity and evaluated the effect on fiber crimping. We found that increasing scaffold porosity increased fiber crimping and ensured that the fibers properly uncrimped as the scaffolds were stretched by minimizing fiber-fiber interactions. Constitutive modeling demonstrated that the fiber uncrimping produced a nonlinear mechanical behavior similar to that of native tendon and ligament. Interestingly, fiber crimping altered strain transmission to the nuclei of cells seeded on the scaffolds, which may account for previously observed changes in gene expression. These crimped biomaterials are useful for developing functional fiber-reinforced tissues and for studying the effects of altered fiber crimping due to damage or degeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.