ArticleOncoimmunology
mRNA Expression levels of genes involved in antitumor immunity: Identification of a 3-gene signature associated with prognosis of muscle-invasive bladder cancer.
Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Review of BCG immunotherapy for bladder cancer.Clinical microbiology reviews · 2025Review
- Modelling the tumor immune microenvironment for precision immunotherapy.Clinical & translational immunology · 2022Review
- Immunoregulated insulitis and slow-progressing type 1 diabetes after duodenopancreatectomy.Diabetologia · 2021Article
- A Novel Immune-Gene Pair Signature Revealing the Tumor Microenvironment Features and Immunotherapy Prognosis of Muscle-Invasive Bladder Cancer.Frontiers in genetics · 2021Article
- Article
- Identification of a 13‑mRNA signature for predicting disease progression and prognosis in patients with bladder cancer.Oncology reports · 2020Article
- Identification of 9-Core Immune-Related Genes in Bladder Urothelial Carcinoma Prognosis.Frontiers in oncology · 2020Article
- Inhibition of PI3K pathway increases immune infiltrate in muscle-invasive bladder cancer.OncoimmunologyArticle
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunotherapy for bladder cancer has given promising results. Here we aimed to evaluate the possible involvement and prognostic value of 33 genes involved in the immune response during bladder carcinogenesis. Expression levels were assessed by quantitative real-time RT-PCR in normal and tumor human bladder samples. Immunohistochemistry was performed to evaluate the protein expression of 2 genes and relation of the mRNA and protein levels was analyzed. Tumors were obtained from 154 patients (83 with muscle-invasive bladder cancer [MIBC] and 71 non-MIBC [NMIBC]) who underwent transurethral bladder resection or radical cystectomy between 2002 and 2006. All patients signed an informed consent. Results of molecular analyses were coupled with survival analyses. Overall, 25 genes (75.8%) were significantly overexpressed in MIBC and 15 (45.5%) were deregulated in NMIBC as compared with normal tissue. On multivariate analysis, risk of NMIBC recurrence was increased with high
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