Evidence map›Paper›PMID 29147531›Full record

ArticleChemical science2017

Catalysis of a 1,3-dipolar reaction by distorted DNA incorporating a heterobimetallic platinum(ii) and copper(ii) complex.

Iván Rivilla, Abel de Cózar, Thomas Schäfer, Frank J Hernandez, Alexander M Bittner, Aitziber Eleta-Lopez, Ali Aboudzadeh, José I Santos, José I Miranda, Fernando P Cossío

Abstract read
In one paragraph

Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Iván RivillaDepartment of Organic Chemistry I , Centro de Innovación en Química Avanzada (ORFEO-CINQA) , Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU) , Donostia International Physics Center (DIPC) , Po Manuel Lardizabal 3 , E-20018 Donostia/San Sebastián , Spain . Email: fp.cossio@ehu.es.ORCID 0000-0003-1984-7183
Abel de CózarDepartment of Organic Chemistry I , Centro de Innovación en Química Avanzada (ORFEO-CINQA) , Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU) , Donostia International Physics Center (DIPC) , Po Manuel Lardizabal 3 , E-20018 Donostia/San Sebastián , Spain . Email: fp.cossio@ehu.es.ORCID 0000-0001-8430-4076
Thomas SchäferIkerbasque, Basque Foundation for Science , Ma Díaz de Haro 3 , E-48013 Bilbao , Spain.ORCID 0000-0002-7550-4807
Frank J HernandezNanoBioSeparations Group , POLYMAT University of the Basque Country (UPV/EHU) , Avda. Tolosa 72 , E-20018 Donostia/San Sebastián , Spain.ORCID 0000-0001-6308-8087
Alexander M BittnerNanoBioSeparations Group , POLYMAT University of the Basque Country (UPV/EHU) , Avda. Tolosa 72 , E-20018 Donostia/San Sebastián , Spain.ORCID 0000-0003-4815-2444
Aitziber Eleta-LopezCIC NanoGUNE , Consolider. Tolosa Hiribidea, 76 , E-200018 Donostia/San Sebastián , Spain.ORCID 0000-0002-2498-1857
Ali AboudzadehNanoBioSeparations Group , POLYMAT University of the Basque Country (UPV/EHU) , Avda. Tolosa 72 , E-20018 Donostia/San Sebastián , Spain.ORCID 0000-0001-8829-8072
José I SantosSGIker NMR Facility , Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU) , Avda. Tolosa 72 , E-20018 Donostia/San Sebastián , Spain.ORCID 0000-0002-5199-2332
José I MirandaSGIker NMR Facility , Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU) , Avda. Tolosa 72 , E-20018 Donostia/San Sebastián , Spain.ORCID 0000-0002-7646-6857
Fernando P CossíoDepartment of Organic Chemistry I , Centro de Innovación en Química Avanzada (ORFEO-CINQA) , Universidad del País Vasco/Euskal Herriko Unibertsitatea (UPV/EHU) , Donostia International Physics Center (DIPC) , Po Manuel Lardizabal 3 , E-20018 Donostia/San Sebastián , Spain . Email: fp.cossio@ehu.es.ORCID 0000-0002-4526-2122

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel catalytic system based on covalently modified DNA is described. This catalyst promotes 1,3-dipolar reactions between azomethine ylides and maleimides. The catalytic system is based on the distortion of the double helix of DNA by means of the formation of Pt(ii) adducts with guanine units. This distortion, similar to that generated in the interaction of DNA with platinum chemotherapeutic drugs, generates active sites that can accommodate

Identifiers

PMID29147531
PMCPMC5637124

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.