ArticleChemical science2017
Multi-component hybrid hydrogels - understanding the extent of orthogonal assembly and its impact on controlled release.
Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 63 citations in OpenAlex.
- Spatially Resolved Diffusion NMR for Structurally Heterogeneous Materials.Analytical chemistry · 2026Article
- pH as a Design Tool for Low-Molecular-Weight Hydrogelators: Triggers, Structural Control, and Orthogonal Assembly.Gels (Basel, Switzerland) · 2026Review
- Four distinct network patterns of supramolecular/polymer composite hydrogels controlled by formation kinetics and interfiber interactions.Nature communications · 2023Article
- Process Dependent Complexity in Multicomponent Gels.Macromolecular rapid communications · 2023Article
- Hybrid hydrogels derived from renewable resources as a smart stimuli responsive soft material for drug delivery applications.RSC advances · 2022Article
- Controlling hydrogel properties by tuning non-covalent interactions in a charge complementary multicomponent system.Chemical science · 2021Article
- Spatial and temporal diffusion-control of dynamic multi-domain self-assembled gels.Chemical science · 2021Article
- Self-assembled low-molecular-weight gelator injectable microgel beads for delivery of bioactive agents.Chemical science · 2021Article
- Supramolecular organogels fabricated with dicarboxylic acids and primary alkyl amines: controllable self-assembled structures.RSC advances · 2020Article
- Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems.Nature communications · 2020Article
- New Developments in Medical Applications of Hybrid Hydrogels Containing Natural Polymers.Molecules (Basel, Switzerland) · 2020Review
- Self-Assembling Supramolecular Hybrid Hydrogel Beads.Angewandte Chemie (International ed. in English) · 2020Article
- Hydrogels as Potential Nano-, Micro- and Macro-Scale Systems for Controlled Drug Delivery.Materials (Basel, Switzerland) · 2020Review
- Supramolecular Self-Assembly To Control Structural and Biological Properties of Multicomponent Hydrogels.Chemistry of materials : a publication of the American Chemical Society · 2019Article
- Mechanistic Insights into the Self-Assembly of an Acid-Sensitive Photoresponsive Supramolecular Polymer.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- Hierarchically Compartmentalized Supramolecular Gels through Multilevel Self-Sorting.Journal of the American Chemical Society · 2019Article
- Supramolecular Organogels Based onNanomaterials (Basel, Switzerland) · 2019Article
- Targetable Mechanical Properties by Switching between Self-Sorting and Co-assembly withChemNanoMat : chemistry of nanomaterials for energy, biology and more · 2018Article
- Diffusion across a gel-gel interface - molecular-scale mobility of self-assembled 'solid-like' gel nanofibres in multi-component supramolecular organogels.Chemical science · 2018Article
- Chiral Assembly Preferences and Directing Effects in Supramolecular Two-Component Organogels.Gels (Basel, Switzerland) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper reports self-assembled multi-component hybrid hydrogels including a range of nanoscale systems and characterizes the extent to which each component maintains its own unique functionality, demonstrating that multi-functionality can be achieved by simply mixing carefully-chosen constituents. Specifically, the individual components are: (i) pH-activated low-molecular-weight gelator (LMWG) 1,3;2,4-dibenzylidenesorbitol-4',4''-dicarboxylic acid (DBS-COOH), (ii) thermally-activated polymer gelator (PG) agarose, (iii) anionic biopolymer heparin, and (iv) cationic self-assembled multivalent (SAMul) micelles capable of binding heparin. The LMWG still self-assembles in the presence of PG agarose, is slightly modified on the nanoscale by heparin, but is totally disrupted by the micelles. However, if the SAMul micelles are bound to heparin, DBS-COOH self-assembly is largely unaffected. The LMWG endows hybrid materials with pH-responsive behavior, while the PG provides mechanical robustness. The rate of heparin release can be controlled through network density and composition, with the LMWG and PG behaving differently in this regard, while the presence of the heparin binder completely inhibits heparin release through complexation. This study demonstrates that a multi-component approach can yield exquisite control over self-assembled materials. We reason that controlling orthogonality in such systems will underpin further development of controlled release systems with biomedical applications.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.