Evidence map›Paper›PMID 29147524›Full record

ArticleChemical science2017

Manipulation of cytokine secretion in human dendritic cells using glycopolymers with picomolar affinity for DC-SIGN.

Daniel A Mitchell, Qiang Zhang, Lenny Voorhaar, David M Haddleton, Shan Herath, Anne S Gleinich, Harpal S Randeva, Max Crispin, Hendrik Lehnert, Russell Wallis and 2 more

Abstract read
In one paragraph

Article in Chemical science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Daniel A MitchellClinical Sciences Research Laboratories , University of Warwick , Coventry CV2 2DX , United Kingdom . Email: d.mitchell@warwick.ac.uk.
Qiang ZhangDepartment of Chemistry , University of Warwick , Coventry CV4 7AL , United Kingdom.
Lenny VoorhaarDepartment of Chemistry , University of Warwick , Coventry CV4 7AL , United Kingdom.
David M HaddletonDepartment of Chemistry , University of Warwick , Coventry CV4 7AL , United Kingdom.ORCID 0000-0002-4965-0827
Shan HerathChelsea & Westminster Hospital , Imperial College School of Medicine , London SW10 9NH , United Kingdom.
Anne S GleinichClinical Sciences Research Laboratories , University of Warwick , Coventry CV2 2DX , United Kingdom . Email: d.mitchell@warwick.ac.uk.
Harpal S RandevaClinical Sciences Research Laboratories , University of Warwick , Coventry CV2 2DX , United Kingdom . Email: d.mitchell@warwick.ac.uk.
Max CrispinGlycobiology Institute , University of Oxford , Oxford OX1 3QU , United Kingdom.
Hendrik LehnertUniversität zu Lübeck , 23562 Lübeck , Germany.
Russell WallisDepartment of Biochemistry , University of Leicester , Leicester LE1 9HN , United Kingdom.
Steven PattersonChelsea & Westminster Hospital , Imperial College School of Medicine , London SW10 9NH , United Kingdom.
C Remzi BecerSchool of Engineering and Materials Science , Queen Mary University , London E1 4NS , United Kingdom . Email: r.becer@qmul.ac.uk.ORCID 0000-0003-0968-6662

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human C-type lectin DC-SIGN (CD209) is a significant receptor on the surface of dendritic cells (DCs) - crucial components of host defense that bridge the innate and adaptive immune systems. A range of linear glycopolymers, constructed

Identifiers

PMID29147524
PMCPMC5642150

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.