Evidence map›Paper›PMID 29147072›Full record

ArticleMediators of inflammation2017

Paradoxical Association of Postoperative Plasma Sphingosine-1-Phosphate with Breast Cancer Aggressiveness and Chemotherapy.

Rajesh Ramanathan, Ali Raza, Jamie Sturgill, Debra Lyon, Jessica Young, Nitai C Hait, Kazuaki Takabe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Rajesh RamanathanDepartment of Surgery, Virginia Commonwealth University Medical Center, 1200 E. Broad St., Richmond, VA, USA.
Ali RazaLincoln Medical and Mental Health Center, Cancer Center, Room 9-69, Bronx, NY, USA.
Jamie SturgillDepartment of Family and Community Health Nursing, Virginia Commonwealth University, 1100 E. Leigh St., Richmond, VA, USA.ORCID 0000-0001-8856-3227
Debra LyonUniversity of Florida, College of Nursing, Gainesville, FL, USA.
Jessica YoungBreast Surgery, Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY, USA.
Nitai C HaitDepartment of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.ORCID 0000-0001-7707-425X
Kazuaki TakabeDepartment of Surgery, Virginia Commonwealth University Medical Center, 1200 E. Broad St., Richmond, VA, USA.ORCID 0000-0002-6435-4241
Roswell Park Comprehensive Cancer Center · USLincoln Medical Center · USUniversity of Florida · USVirginia Commonwealth University Medical Center · US

Funding

Sphingosine-1 Phosphate in Breast Cancer Progression and LymphangiogenesisR01CA160688 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI TAKABE, KAZUAKI · 2012 to 2016
$1.5M
NCI NIH HHS R01 CA160688
6 · The paper itself

Abstract

Sphingosine-1-phosphate (S1P) is a bioactive lipid mediator that has been shown to serve an important regulatory function in breast cancer progression. This study analyzes plasma S1P levels in breast cancer patients undergoing adjuvant therapy as compared to healthy control volunteers. 452 plasma S1P samples among 158 breast cancer patients, along with 20 healthy control volunteers, were analyzed. Mean S1P levels did not significantly differ between cancer patients and controls. Smoking was associated with higher S1P levels in cancer patients. Baseline S1P levels had weak inverse correlation with levels of the inflammatory mediator interleukin- (IL-) 17 and CCL-2 and positive correlation with tumor necrosis factor alpha (TNF-

Indexed as

AdultBody Mass IndexBreast NeoplasmsChemokine CCL2FemaleHumansInterleukin-17LysophospholipidsMiddle AgedPostoperative PeriodSmokingSphingosineTumor Necrosis Factor-alphaChemokine CCL2Interleukin-17LysophospholipidsSphingosinesphingosine 1-phosphateTumor Necrosis Factor-alpha

Identifiers

PMID29147072
PMCPMC5632905
OpenAlexW2757027592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.