Evidence map›Paper›PMID 29147026›Full record

ArticleScientific reports2017

Leveraging genome characteristics to improve gene discovery for putamen subcortical brain structure.

Chi-Hua Chen, Yunpeng Wang, Min-Tzu Lo, Andrew Schork, Chun-Chieh Fan, Dominic Holland, Karolina Kauppi, Olav B Smeland, Srdjan Djurovic, Nilotpal Sanyal and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. KTN1 variants and risk for attention deficit hyperactivity disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2020
    Article
  9. Frontiers in neuroscience · 2020
    Article
  10. Article
  11. Putamen gray matter volumes in neuropsychiatric and neurodegenerative disorders.World journal of psychiatry and mental health research · 2019
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chi-Hua ChenCenter for Multimodal Imaging and Genetics, Department of Radiology, University of California, San Diego, La Jolla, California, 92093, USA. chc101@ucsd.edu.
Yunpeng WangDepartment of Neurosciences, University of California, San Diego, La Jolla, California, 92093, USA.ORCID 0000-0001-9831-1090
Min-Tzu LoCenter for Multimodal Imaging and Genetics, Department of Radiology, University of California, San Diego, La Jolla, California, 92093, USA.
Andrew SchorkCenter for Multimodal Imaging and Genetics, Department of Radiology, University of California, San Diego, La Jolla, California, 92093, USA.
Chun-Chieh FanCenter for Multimodal Imaging and Genetics, Department of Radiology, University of California, San Diego, La Jolla, California, 92093, USA.ORCID 0000-0001-9437-2128
Dominic HollandDepartment of Neurosciences, University of California, San Diego, La Jolla, California, 92093, USA.
Karolina KauppiCenter for Multimodal Imaging and Genetics, Department of Radiology, University of California, San Diego, La Jolla, California, 92093, USA.ORCID 0000-0003-4908-341X
Olav B SmelandDepartment of Neurosciences, University of California, San Diego, La Jolla, California, 92093, USA.ORCID 0000-0002-3761-5215
Srdjan DjurovicDepartment of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Nilotpal SanyalCenter for Multimodal Imaging and Genetics, Department of Radiology, University of California, San Diego, La Jolla, California, 92093, USA.
Derrek P HibarImaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, 90027, USA.
Paul M ThompsonImaging Genetics Center, Mark and Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey, California, 90027, USA.
Wesley K ThompsonDivision of Biostatistics, Department of Family Medicine and Public Health, University of California, San Diego, La Jolla, California, 92093, USA.
Ole A AndreassenNORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-4461-3568
Anders M DaleCenter for Multimodal Imaging and Genetics, Department of Radiology, University of California, San Diego, La Jolla, California, 92093, USA.

Funding

Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Growth factors, neuroinflammation, exercise, and brain integrityRF1AG041915 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2014
$2.9M
Alzheimer's disease risk analyzed using population imaging genomicsR01AG040060 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2011 to 2016
$2.5M
Identifying the Polygenic Basis of the Human Brain and Psychiatric DisordersR01MH100351 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, CHI-HUA · 2013 to 2017
$2.1M
Polygenicity, Pleiotrophy and Power: Novel Statistical Methods for Gene DiscoveryR01GM104400 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THOMPSON, WESLEY KURT · 2014 to 2017
$1.6M
NIA NIH HHS R01 AG040060NIA NIH HHS RF1 AG041915NIBIB NIH HHS U54 EB020403NIGMS NIH HHS R01 GM104400NIMH NIH HHS R01 MH100351
6 · The paper itself

Abstract

Discovering genetic variants associated with human brain structures is an on-going effort. The ENIGMA consortium conducted genome-wide association studies (GWAS) with standard multi-study analytical methodology and identified several significant single nucleotide polymorphisms (SNPs). Here we employ a novel analytical approach that incorporates functional genome annotations (e.g., exon or 5'UTR), total linkage disequilibrium (LD) scores and heterozygosity to construct enrichment scores for improved identification of relevant SNPs. The method provides increased power to detect associated SNPs by estimating stratum-specific false discovery rate (FDR), where strata are classified according to enrichment scores. Applying this approach to the GWAS summary statistics of putamen volume in the ENIGMA cohort, a total of 15 independent significant SNPs were identified (conditional FDR < 0.05). In contrast, 4 SNPs were found based on standard GWAS analysis (P < 5 × 10

Indexed as

Genome, HumanGenome-Wide Association StudyHumansPolymorphism, Single NucleotidePutamen

Identifiers

PMID29147026
PMCPMC5691156

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.