ArticleScientific reports2017
A new method to measure mechanics and dynamic assembly of branched actin networks.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- A Magnetic Pincher for the Dynamic Measurement of the Actin Cortex Thickness in Live Cells.Methods in molecular biology (Clifton, N.J.) · 2024Article
- How dynamic prestress governs the shape of living systems, from the subcellular to tissue scale.Interface focus · 2022Review
- Biochemical and mechanical regulation of actin dynamics.Nature reviews. Molecular cell biology · 2022Review
- Pinching the cortex of live cells reveals thickness instabilities caused by myosin II motors.Science advances · 2021Article
- Programmable Design and Performance of Modular Magnetic Microswimmers.Advanced materials (Deerfield Beach, Fla.) · 2021Article
- Mechanical stiffness of reconstituted actin patches correlates tightly with endocytosis efficiency.PLoS biology · 2019Article
- Kinetics of surface growth with coupled diffusion and the emergence of a universal growth path.Proceedings. Mathematical, physical, and engineering sciences · 2019Article
- Strain-Stiffening in Dynamic Supramolecular Fiber Networks.Journal of the American Chemical Society · 2018Article
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Authors and funding
6 authors.
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Abstract
We measured mechanical properties and dynamic assembly of actin networks with a new method based on magnetic microscopic cylinders. Dense actin networks are grown from the cylinders' surfaces using the biochemical Arp2/3-machinery at play in the lamellipodium extension and other force-generating processes in the cell. Under a homogenous magnetic field the magnetic cylinders self-assemble into chains in which forces are attractive and depend on the intensity of the magnetic field. We show that these forces, from piconewtons to nanonewtons, are large enough to slow down the assembly of dense actin networks and controlled enough to access to their non linear mechanical responses. Deformations are measured with nanometer-resolution, well below the optical resolution. Self-assembly of the magnetic particles into chains simplifies experiments and allows for parallel measurements. The combination of accuracy and good throughput of measurements results in a method with high potential for cell and cytoskeleton mechanics. Using this method, we observed in particular a strong non linear mechanical behavior of dense branched actin networks at low forces that has not been reported previously.
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