Evidence map›Paper›PMID 29146967›Full record

ArticleScientific reports2017

Splenic glucocorticoid resistance following psychosocial stress requires physical injury.

Sandra Foertsch, Andrea M Füchsl, Sandra D Faller, Hannah Hölzer, Dominik Langgartner, Joanna Messmann, Gudrun Strauß, Stefan O Reber

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. SubcutaneousNeurobiology of stress · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Old Friends, immunoregulation, and stress resilience.Pflugers Archiv : European journal of physiology · 2019
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sandra FoertschLaboratory for Molecular Psychosomatics, Clinic for Psychosomatic Medicine and Psychotherapy, University Ulm, Ulm, Germany.
Andrea M FüchslLaboratory for Molecular Psychosomatics, Clinic for Psychosomatic Medicine and Psychotherapy, University Ulm, Ulm, Germany.
Sandra D FallerLaboratory for Molecular Psychosomatics, Clinic for Psychosomatic Medicine and Psychotherapy, University Ulm, Ulm, Germany.
Hannah HölzerLaboratory for Molecular Psychosomatics, Clinic for Psychosomatic Medicine and Psychotherapy, University Ulm, Ulm, Germany.
Dominik LanggartnerLaboratory for Molecular Psychosomatics, Clinic for Psychosomatic Medicine and Psychotherapy, University Ulm, Ulm, Germany.
Joanna MessmannDepartment of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.
Gudrun StraußDepartment of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.
Stefan O ReberLaboratory for Molecular Psychosomatics, Clinic for Psychosomatic Medicine and Psychotherapy, University Ulm, Ulm, Germany. stefan.reber@uniklinik-ulm.de.ORCID 0000-0002-1583-7618
University Hospital Ulm · DEUniversität Ulm · DEUniversity of Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mice exposed to chronic subordinate colony housing (CSC) stress show glucocorticoid (GC) resistance of in vitro lipopolysaccharide (LPS)-stimulated splenocytes, increased anxiety and colitis. Similar effects were reported in wounded mice exposed to social disruption (SDR). Here we show that CSC exposure induced GC resistance in isolated and in vitro LPS-stimulated, but not unstimulated, splenocytes, and these effects were absent when CD11b

Indexed as

AnimalsChronic DiseaseDrug ResistanceGlucocorticoidsHousing, AnimalMaleMice, Inbred C57BLSpleenStress, PsychologicalGlucocorticoids

Identifiers

PMID29146967
PMCPMC5691078
OpenAlexW2767633590

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.