ArticleScientific reports2017
Frailty is an independent predictor of incident dementia: Evidence from the English Longitudinal Study of Ageing.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 3 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Multi-Concept Frailty Predicts the Late-Life Occurrence of Cognitive Decline or Dementia: An Updated Systematic Review and Meta-Analysis of Longitudinal Studies.Frontiers in aging neuroscience · 2022Pooled it
- Defining end of life in dementia: A systematic review.Palliative medicine · 2021Pooled it
- Frailty status and the risk of dementia, Alzheimer's disease: a meta-analysis of observational studies.Frontiers in neurologyPooled it
- Frailty and functional brain connectivity (FBC) in older adults with mild cognitive impairment (MCI): baseline results from the SYNERGIC Trial.GeroScience · 2023Trial
- Trial
- Longitudinal dynamics in frailty and incident all-cause dementia: a multicohort study.Journal of advanced research · 2026Article
- Frailty and incident cognitive impairment in patients with CKD: sex-frailty paradox in the Chronic Renal Insufficiency Cohort (CRIC).GeroScience · 2026Article
- Frailty index predicts the risk of 17 health outcomes in distinct ways: prospective findings from the Moli-sani Study.Age and ageing · 2026Article
- Association of cumulative deficit frailty with brain age and Alzheimer's disease-related brain structure starting in late-middle age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Prevalence of frailty and its association with cognition in preclinical Alzheimer's disease: a cross-sectional analysis of baseline data from the A4 study.Age and ageing · 2026Article
- Association between frailty and incidence of AMD among middle-aged and older people: evidence from the UK Biobank.Frontiers in aging · 2026Article
- Association of transitions in frailty with dementia risk: findings from two longitudinal cohort studies.Frontiers in medicine · 2026Article
- Infections and cognitive function, depression, and frailty: a cross-sectional study in the longitudinal aging study in India (LASI).BMC public health · 2025Article
- Does Frailty Predict Cognitive and Functional Deficits After Nine Years?International journal of geriatric psychiatry · 2025Article
- Peptide Family Promotes Brain Cell Rejuvenation and Improved Cognition through Peripheral Delivery.ACS omega · 2025Article
- Association of Longitudinal Trajectories of Physical Frailty With Dementia Status in Older Adults: A National Cohort Study.International journal of geriatric psychiatry · 2025Article
- Sustained frailty remission and dementia risk in older adults: A longitudinal study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Frailty trajectories preceding dementia: an individual-level analysis of four cohort studies in the United States and United Kingdom.Research square · 2024Article
- Midlife cumulative deficit frailty predicts Alzheimer's disease-related plasma biomarkers in older adults.Age and ageing · 2024Article
- To Be Frail or Not to Be Frail: This Is the Question-A Critical Narrative Review of Frailty.Journal of clinical medicine · 2024Review
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The aim of this study was to determine whether frailty in older adults is associated with the risk of subsequent dementia. A total of 8,722 older adults from the English Longitudinal Study of Ageing were followed-up every two years until they reported a diagnosis of dementia, died, or were right censored. Frailty was defined using a frailty index comprised of 47 health deficits. To test if cognitive function influences the relationship between frailty and incident dementia, the analyses were repeated according to lower or upper three quartiles of baseline cognitive function. Competing risks regression and Cox proportional hazard models were used to evaluate whether the degree of baseline frailty was associated with incident dementia. Compared with non-frail participants, pre-frail (HR: 1.51 95%CI [1.12-2.02]) and frail participants (HR: 1.73 95%CI [1.22-2.43]) had a higher risk of developing dementia, after adjustment for covariates. The association between frailty and incident dementia was significant for adults in the upper three quartiles of global cognitive function (HR: 3.48 95%CI [1.98-6.12]), but not for adults who were in the lowest quartile of cognitive function (HR: 1.13 95%CI [0.74-1.71]). Frailty should be monitored alongside cognitive functioning when assessing risk factors for dementia in older adults.
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