Evidence map›Paper›PMID 29146945›Full record

ArticleScientific reports2017

Maraba virus-vectored cancer vaccines represent a safe and novel therapeutic option for cats.

Jeff Hummel, Dorothee Bienzle, Annette Morrison, Michelle Cieplak, Kyle Stephenson, Josepha DeLay, J Paul Woods, Brian D Lichty, Byram W Bridle

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Personalizing Oncolytic Immunovirotherapy Approaches.Molecular diagnosis & therapy · 2024
    Article
  6. Review
  7. Use of Precision-Cut Lung Slices as anMolecular therapy. Methods & clinical development · 2018
    Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jeff HummelMcMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, L8S 4L8, Canada.ORCID 0000-0002-8967-7944
Dorothee BienzleDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada.ORCID 0000-0002-2301-2931
Annette MorrisonCentral Animal Facility, University of Guelph, Guelph, Ontario, N1G 2W1, Canada.
Michelle CieplakCentral Animal Facility, University of Guelph, Guelph, Ontario, N1G 2W1, Canada.
Kyle StephensonMcMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, L8S 4L8, Canada.
Josepha DeLayAnimal Health Laboratory, University of Guelph, Guelph, Ontario, N1G 2W1, Canada.
J Paul WoodsDepartment of Clinical Studies, University of Guelph, Guelph, Ontario, N1G 2W1, Canada.
Brian D LichtyMcMaster Immunology Research Centre, McMaster University, Hamilton, Ontario, L8S 4L8, Canada.
Byram W BridleDepartment of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1, Canada. bbridle@uoguelph.ca.ORCID 0000-0002-8335-1118
University of Guelph · CAMcMaster University Medical Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Direct killing of malignant cells combined with induction of tumour-specific immune responses makes oncolytic vaccines attractive for cancer therapy. We previously developed a heterologous cancer immunization strategy that utilized a replication-defective adenovirus-vectored primary vaccine encoding a tumour antigen followed by boosting with a replication-competent Maraba virus expressing the same antigen. To assess the safety of oncolytic Maraba virus-based booster vaccines and inform the design of clinical trials, we conducted translational studies in cats, which have immune systems that are similar to people and spontaneously develop cancers of comparable types and etiologies. A dose of Maraba virus up to 2.5 × 10

Indexed as

Acute DiseaseAnimalsBlood Cell CountBody TemperatureCancer VaccinesCatsFemaleFeverGenetic VectorsGenome, ViralOncolytic VirusesOrgan SpecificityPilot ProjectsSalivationTissue DistributionVaccinationCancer Vaccines

Identifiers

PMID29146945
PMCPMC5691073
OpenAlexW2767446987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.