ArticleNature communications2017
Alternative transcription start site selection in Mr-OPY2 controls lifestyle transitions in the fungus Metarhizium robertsii.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Entomopathogenic fungi: beyond biocontrol-unravelling mechanisms of enhanced plant abiotic stress tolerance.Crop health · 2026Review
- The patterns of alternative TSS usage explain the highly heterogeneous landscape of 5'UTR lengths in eukaryotes.NAR genomics and bioinformatics · 2025Article
- Mapping genomic regions associated with temperature stress in the wheat pathogen Zymoseptoria tritici.G3 (Bethesda, Md.) · 2025Article
- Transcription Factors in Biocontrol Fungi.Journal of fungi (Basel, Switzerland) · 2025Review
- Mr-lac3 and Mr-lcc2 inJournal of fungi (Basel, Switzerland) · 2025Article
- Histone deacetylase HDAC3 regulates ergosterol production for oxidative stress tolerance in the entomopathogenic and endophytic fungusmSystems · 2024Article
- The secretory protein COA1 enables Metarhizium robertsii to evade insect immune recognition during cuticle penetration.Communications biology · 2024Article
- Discovering the hidden function in fungal genomes.Nature communications · 2024Review
- Two aminopeptidase I homologs convergently contribute to pathobiology of fungal entomopathogen Beauveria bassiana via divergent physiology-dependent autophagy pathways for vacuolar targeting.Journal of advanced research · 2024Article
- Autophagy-Related Gene 4 Participates in the Asexual Development, Stress Response and Virulence of Filamentous Insect Pathogenic FungusJournal of fungi (Basel, Switzerland) · 2023Article
- Divergent Physiological Functions of Four Atg22-like Proteins in Conidial Germination, Development, and Virulence of the Entomopathogenic FungusJournal of fungi (Basel, Switzerland) · 2023Article
- New insights into genome annotation in Podospora anserina through re-exploiting multiple RNA-seq data.BMC genomics · 2022Article
- Alternative Transcription Start Site Usage and Functional Implications in Pathogenic Fungi.Journal of fungi (Basel, Switzerland) · 2022Review
- Protein kinase Ime2 is associated with mycelial growth, conidiation, osmoregulation, and pathogenicity in Fusarium oxysporum.Archives of microbiology · 2022Article
- Host-Pathogen Interactions betweenJournal of fungi (Basel, Switzerland) · 2022Review
- MaOpy2, a Transmembrane Protein, Is Involved in Stress Tolerances and Pathogenicity and Negatively Regulates Conidial Yield by Shifting the Conidiation Pattern inJournal of fungi (Basel, Switzerland) · 2022Article
- Genomic signatures and insights into host niche adaptation of the entomopathogenic fungus Metarhizium humberi.G3 (Bethesda, Md.) · 2022Article
- New Downstream Signaling Branches of the Mitogen-Activated Protein Kinase Cascades Identified in the Insect Pathogenic and Plant Symbiotic FungusFrontiers in fungal biology · 2022Review
- The Deubiquitinating EnzymeFrontiers in fungal biology · 2022Article
- Slt2-MAPK/RNS1 Controls Conidiation via Direct Regulation of the Central Regulatory Pathway in the FungusJournal of fungi (Basel, Switzerland) · 2021Article
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Authors and funding
10 authors.
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Abstract
Metarhizium robertsii is a versatile fungus with saprophytic, plant symbiotic and insect pathogenic lifestyle options. Here we show that M. robertsii mediates the saprophyte-to-insect pathogen transition through modulation of the expression of a membrane protein, Mr-OPY2. Abundant Mr-OPY2 protein initiates appressorium formation, a prerequisite for infection, whereas reduced production of Mr-OPY2 elicits saprophytic growth and conidiation. The precise regulation of Mr-OPY2 protein production is achieved via alternative transcription start sites. During saprophytic growth, a single long transcript is produced with small upstream open reading frames in its 5' untranslated region. Increased production of Mr-OPY2 protein on host cuticle is achieved by expression of a transcript variant lacking a small upstream open reading frame that would otherwise inhibit translation of Mr-OPY2. RNA-seq and qRT-PCR analyses show that Mr-OPY2 is a negative regulator of a transcription factor that we demonstrate is necessary for appressorial formation. These findings provide insights into the mechanisms regulating fungal lifestyle transitions.
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