ArticleArteriosclerosis, thrombosis, and vascular biology2018
TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice.
Open access · bronzeAbstract readVideo-Audio Media
In one paragraph
Article in Arteriosclerosis, thrombosis, and vascular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Neuroprotective role of carvacrol in ischemic brain injury: a systematic review of preclinical evidence and proposed TRPM7 involvement.Frontiers in pharmacology · 2025Pooled it
- The Association of Gut Microbiota With TRPM7 Genotype, Colorectal Polyps, and Magnesium.The Journal of nutrition · 2025Trial
- TRPM7 kinase: a target for multimodal drug development in neurological disorders.Acta pharmacologica Sinica · 2026Review
- Mechanisms and Therapeutic Targets of Ischemia-Reperfusion Injury in Stroke: A Narrative Review Focusing on Blood-Brain Barrier Dysfunction.Brain sciences · 2026Review
- TRPM7 kinase inhibitor TG100-115 provides neuroprotection against neonatal hypoxic-ischemic brain injury.Acta pharmacologica Sinica · 2026Article
- Stratified assessment of platelets in sepsis: from dynamic counts to functional phenotypes.Frontiers in immunology · 2026Review
- A Boolean Seven-Layer Platelet Decision Model Models Consistently the Logic and Semiquantitatively the Dynamics of Platelet Activation and Inhibition.Computational and structural biotechnology journal · 2026Article
- Cardiac TRPM7 Causes Diabetic Heart Failure With Preserved Ejection Fraction.JACC. Basic to translational science · 2025Article
- Article
- The interaction between dysfunction of vasculature and tauopathy in Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Unlocking TRPM7 interactions: A database-driven quest.Computational and structural biotechnology journal · 2025Review
- The role and mechanism of vascular wall cell ion channels in vascular fibrosis remodeling.Channels (Austin, Tex.) · 2024Review
- Article
- C-type lectin-like receptor 2: roles and drug target.Thrombosis journal · 2024Review
- Ion Channel Dysregulation Following Intracerebral Hemorrhage.Neuroscience bulletin · 2024Review
- Beyond Ion Homeostasis: Hypomagnesemia, Transient Receptor Potential Melastatin Channel 7, Mitochondrial Function, and Inflammation.Nutrients · 2023Article
- Bilirubin gates the TRPM2 channel as a direct agonist to exacerbate ischemic brain damage.Neuron · 2023Article
- TRPM7 kinase mediates hypomagnesemia-induced seizure-related death.Scientific reports · 2023Article
- Hypomagnesemia and Cardiovascular Risk in Type 2 Diabetes.Endocrine reviews · 2023Article
- COVID-19-induced neurological symptoms: focus on the role of metal ions.Inflammopharmacology · 2023Review
Corrections and comments
- Commented on by
Authors and funding
21 authors at 4 institutions in 3 countries.
Sanjeev K GotruFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.).
Wenchun ChenFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.).
Peter KraftFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.).
Isabelle C BeckerFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.).
Karen WolfFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.).
Simon StrittFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.).
Susanna ZierlerFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.).
Heike M HermannsFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.).
Deviyani RaoFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.).
Anne-Laure PerraudFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.).
Carsten SchmitzFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.).
René P ZahediFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.).
Peter J NoyFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.).
Michael G TomlinsonFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.).
Thomas DandekarFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.).
Masayuki MatsushitaFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.).
Vladimir ChubanovFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.).
Thomas GudermannFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.).
Guido StollFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.).
Bernhard NieswandtFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.). attila.braun@virchow.uni-wuerzburg.de bernhard.nieswandt@virchow.uni-wuerzburg.de.
Attila BraunFrom the Institute of Experimental Biomedicine, University Hospital of Würzburg (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), Rudolf Virchow Center (S.K.G., W.C., I.C.B., K.W., S.S., B.N., A.B.), and Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center (P.K.), University of Würzburg, Germany; Department of Hepatology (H.M.H.) and Department of Neurology (P.K., G.S.), University Hospital of Würzburg, Germany; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig Maximilian University of Munich, Germany (S.Z., V.C., T.G.); Department of Immunology and Microbiology, University of Colorado, Denver (D.R., A.-L.P., C.S.); National Jewish Health, Denver, CO (D.R., A.-L.P., C.S.); Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan (M.M.); Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany (R.P.Z.); School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, United Kingdom (P.J.N., M.G.T.); and Department of Bioinformatics, Functional Genomics and Systems Biology Group, University of Würzburg Biocenter, Germany (T.D.). attila.braun@virchow.uni-wuerzburg.de bernhard.nieswandt@virchow.uni-wuerzburg.de.
University of the Ryukyus · JPNational Jewish Health · USUniversity of Colorado Denver · USUniversity of Birmingham · GB
Funding
Structure-function relationships of the chimeric TRPM7 channel-kinaseR01GM090123 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI SCHMITZ, CARSTEN · 2010 to 2014
$1.4MCellular regulation of magnesium homeostasisR01GM068801 · NIGMS · NATIONAL JEWISH HEALTH · PI PERRAUD, ANNE-LAURE · 2004 to 2008
$1.3MThe Role of Magnesium in B-Cell SignalingK08AI060926 · NIAID · UNIVERSITY OF COLORADO DENVER · PI SCHMITZ, CARSTEN · 2004 to 2006
$323kNIAID NIH HHS K08 AI060926NIGMS NIH HHS R01 GM068801NIGMS NIH HHS R01 GM090123
Abstract
objectiveTRPM7 (transient receptor potential cation channel, subfamily M, member 7) is a ubiquitously expressed bifunctional protein comprising a transient receptor potential channel segment linked to a cytosolic α-type serine/threonine protein kinase domain. TRPM7 forms a constitutively active Mg APPROACH AND
resultsHere we show that point mutation in TRPM7 kinase domain deleting the kinase activity in mice (
conclusionsOur results identify TRPM7 kinase as a key modulator of phospholipase C signaling and store-operated Ca
Indexed as
Calcium SignalingAnimalsArterial Occlusive DiseasesBlood PlateletsCalciumDisease Models, AnimalInfarction, Middle Cerebral ArteryLectins, C-TypeMice, Mutant StrainsPhosphatidylinositol 4,5-DiphosphatePhospholipase C betaPhospholipase C gammaPhosphorylationPlatelet Membrane GlycoproteinsPoint MutationReceptors, Proteinase-ActivatedCalciumCLEC-2 protein, mouseLectins, C-TypePhosphatidylinositol 4,5-DiphosphatePhospholipase C betaPhospholipase C gammaPlatelet Membrane Glycoproteinsplatelet membrane glycoprotein VIPlcb3 protein, mouseReceptors, Proteinase-ActivatedStim1 protein, mouseStromal Interaction Molecule 1SynaptophysinSyp protein, mouseTrpm7 protein, mouseTRPM Cation Channelsblood plateletsstore-operated calcium entrystrokethrombosisTRPM7
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