Evidence map›Paper›PMID 29146695›Full record

Trial reportJournal of nuclear medicine : official publication, Society of Nuclear Medicine2018

First-in-Human Human Epidermal Growth Factor Receptor 2-Targeted Imaging Using

Gary A Ulaner, Serge K Lyashchenko, Christopher Riedl, Shutian Ruan, Pat B Zanzonico, Diana Lake, Komal Jhaveri, Brian Zeglis, Jason S Lewis, Joseph A O'Donoghue

Open access · bronzeAbstract readClinical Trial
In one paragraph

Trial report in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 2 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 2 syntheses or guidelines pooled it, 178 citations in OpenAlex.

  1. Joint EANM-SNMMI guideline on the role of 2-[European journal of nuclear medicine and molecular imaging · 2024
    Guideline
  2. Pooled it
  3. Imaging with [The Lancet. Oncology · 2024
    Trial
  4. Phase I Study ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Trial
  5. Trial
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Radiopharmaceuticals and their applications in medicine.Signal transduction and targeted therapy · 2025
    Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Gary A UlanerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York ulanerg@mskcc.org.
Serge K LyashchenkoDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Christopher RiedlDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Shutian RuanDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.
Pat B ZanzonicoDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.
Diana LakeDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Komal JhaveriDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Brian ZeglisDepartment of Chemistry, Hunter College, New York, New York; and.
Jason S LewisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York.
Joseph A O'DonoghueDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York.
Memorial Sloan Kettering Cancer Center · USCornell University · USHunter College · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
The Clinical PET Imaging of Metastatic Breast Cancer with Site-Specifically Labeled 89Zr-TrastuzumabR01CA204167 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S., ULANER, GARY ALLAN · 2016 to 2020
$3.4M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA204167
6 · The paper itself

Abstract

In what we believe to be a first-in-human study, we evaluated the safety and dosimetry of

Indexed as

Antibodies, Monoclonal, HumanizedPositron Emission Tomography Computed TomographyRadioisotopesZirconiumAdultAgedBreast NeoplasmsErb-b2 Receptor Tyrosine KinasesFemaleHumansMiddle AgedNeoplasm MetastasisRadiometryTissue DistributionAntibodies, Monoclonal, HumanizedERBB2 protein, humanErb-b2 Receptor Tyrosine KinasespertuzumabRadioisotopesZirconiumZirconium-8989Zr-pertuzumabbreast cancerdosimetryoncologyPET/CTradiobiology

Identifiers

PMID29146695
PMCPMC6004559
OpenAlexW2769853159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.