Evidence map›Paper›PMID 29146601›Full record

ArticleThe European respiratory journal2017

Airway microbiota across age and disease spectrum in cystic fibrosis.

Edith T Zemanick, Brandie D Wagner, Charles E Robertson, Richard C Ahrens, James F Chmiel, John P Clancy, Ronald L Gibson, William T Harris, Geoffrey Kurland, Theresa A Laguna and 9 more

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in The European respiratory journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 1 pooled it
18.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 1 synthesis or guideline pooled it, 225 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. The redefined identity ofJournal of bacteriology · 2026
    Review
  6. Review
  7. Article
  8. The effect ofiScience · 2026
    Article
  9. Article
  10. Pulmonary mucoidMicrobiology spectrum · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Journal of bacteriology · 2025
    Article
  18. Article
  19. Review
  20. Article

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 14 institutions in 1 country.

Edith T ZemanickUniversity of Colorado School of Medicine, Aurora, CO, USA edith.zemanick@childrenscolorado.org.
Brandie D WagnerUniversity of Colorado School of Medicine, Aurora, CO, USA.
Charles E RobertsonUniversity of Colorado School of Medicine, Aurora, CO, USA.
Richard C AhrensUniversity of Iowa, Iowa City, IA, USA.
James F ChmielCase Western Reserve University School of Medicine, Rainbow Babies and Children's Hospital, Cleveland, OH, USA.
John P ClancyCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Ronald L GibsonUniversity of Washington, Seattle Children's Hospital, Seattle, WA, USA.
William T HarrisUniversity of Alabama, Birmingham, AL, USA.
Geoffrey KurlandChildren's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Theresa A LagunaUniversity of Minnesota, Minneapolis, MN, USA.
Susanna A McColleyAnn and Robert H. Lurie Children's Hospital of Chicago and Northwestern University, Chicago, IL, USA.
Karen McCoyNationwide Children's Hospital, Columbus, OH, USA.
George Retsch-BogartUniversity of North Carolina, Chapel Hill, NC, USA.
Kurtis T SobushSt Louis University School of Medicine, St Louis, MO, USA.
Pamela L ZeitlinJohns Hopkins University, Baltimore, MD, USA.
Mark J StevensUniversity of Colorado School of Medicine, Aurora, CO, USA.
Frank J AccursoUniversity of Colorado School of Medicine, Aurora, CO, USA.
Scott D SagelUniversity of Colorado School of Medicine, Aurora, CO, USA.
J Kirk HarrisUniversity of Colorado School of Medicine, Aurora, CO, USA.
University of Colorado Denver · USChildren's Hospital of Pittsburgh · USCincinnati Children's Hospital Medical Center · USColorado School of Public Health · USJohns Hopkins University · USLurie Children's Hospital · USNationwide Children's Hospital · USRainbow Babies & Children's Hospital · USSaint Louis University · USUniversity of Alabama at Birmingham · USUniversity of Iowa · USUniversity of Minnesota · USUniversity of North Carolina at Chapel Hill · USUniversity of Washington · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Airway Microbiome in Cystic Fibrosis Pulmonary ExacerbationsK23HL114883 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ZEMANICK, EDITH TOWLER · 2014 to 2017
$615k
NCATS NIH HHS UL1 TR001082NHLBI NIH HHS K23 HL114883
6 · The paper itself

Abstract

Our objectives were to characterise the microbiota in cystic fibrosis (CF) bronchoalveolar lavage fluid (BALF), and determine its relationship to inflammation and disease status.BALF from paediatric and adult CF patients and paediatric disease controls undergoing clinically indicated bronchoscopy was analysed for total bacterial load and for microbiota by 16S rDNA sequencing.We examined 191 BALF samples (146 CF and 45 disease controls) from 13 CF centres. In CF patients aged <2 years, nontraditional taxa (

Indexed as

Age FactorsMicrobiotaAdolescentAdultBronchoalveolar Lavage FluidCase-Control StudiesChildChild, PreschoolCystic FibrosisDisease ProgressionDNA, BacterialFemaleHumansInfantInflammationLungDNA, Bacterial

Identifiers

PMID29146601
PMCPMC5935257
OpenAlexW2770873502

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.