Evidence map›Paper›PMID 29146590›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

CaMKIIα Mediates the Effect of IL-17 To Promote Ongoing Spontaneous and Evoked Pain in Multiple Sclerosis.

Xiaoyu Hu, Fang Huang, Zaijie Jim Wang

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Neurons promote encephalitogenic CD4Scientific reports · 2020
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Xiaoyu HuDepartment of Biopharmaceutical Sciences and Cancer Center, University of Illinois, Chicago, Illinois 60612.
Fang HuangDepartment of Biopharmaceutical Sciences and Cancer Center, University of Illinois, Chicago, Illinois 60612.
Zaijie Jim WangDepartment of Biopharmaceutical Sciences and Cancer Center, University of Illinois, Chicago, Illinois 60612 zjwang@uic.edu.
University of Illinois Urbana-Champaign · US

Funding

Molecular mechanism and targeting of chronic pain in sickle cell diseaseR35HL140031 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI WANG, ZAIJIE JIM · 2018 to 2024
$4.6M
Cortical opioid dysfunction in chronic painR01DA041809 · NIDA · UNIVERSITY OF ARIZONA · PI PORRECA, FRANK, WANG, ZAIJIE JIM · 2016 to 2020
$2.7M
Protein kinase mechanisms for chronic pain in sickle cell diseaseR01HL098141 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI WANG, ZAIJIE JIM · 2009 to 2017
$2.6M
NHLBI NIH HHS R01 HL098141NHLBI NIH HHS R35 HL140031NIDA NIH HHS R01 DA041809
6 · The paper itself

Abstract

Pain is a common and severe symptom in multiple sclerosis (MS), a chronic inflammatory and demyelinating disease of the CNS. The neurobiological mechanism underlying MS pain is poorly understood. In this study, we investigated the role of Ca

Indexed as

AnimalsBenzenesulfonamidesBenzylaminesCalcium-Calmodulin-Dependent Protein Kinase Type 2Encephalomyelitis, Autoimmune, ExperimentalFemaleHyperalgesiaInterleukin-17MiceMice, Inbred C57BLMultiple SclerosisPainPhosphorylationPoint MutationPostural BalanceRNA, Small InterferingBenzenesulfonamidesBenzylaminesCalcium-Calmodulin-Dependent Protein Kinase Type 2Camk2a protein, mouseIl17a protein, mouseInterleukin-17KN 93RNA, Small InterferingSulfonamidesCaMKIIαEAEkinasemultiple sclerosispainphosphorylation

Identifiers

PMID29146590
PMCPMC5761434
OpenAlexW2770104614

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.