ArticleThe Journal of allergy and clinical immunology2018
Obstruction phenotype as a predictor of asthma severity and instability in children.
Article in The Journal of allergy and clinical immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Mechanistic study of inspiratory training in childhood Asthma: Rationale and methods of a pediatric clinical trial.Contemporary clinical trials communications · 2026Article
- Preserved ratio impaired spirometry, dysanapsis and airflow obstruction with low forced expiratory volume in 1 s in childhood asthma.ERJ open research · 2025Article
- A new approach to computed tomography measurement of airway remodelling in paediatric asthma.ERJ open research · 2024Article
- Prediction of Asthma Exacerbations in Children.Journal of personalized medicine · 2023Review
- Incidence rates of childhood asthma with recurrent exacerbations in the US Environmental influences on Child Health Outcomes (ECHO) program.The Journal of allergy and clinical immunology · 2023Article
- Indoor environmental exposures and obstructive lung disease phenotypes among children with asthma living in poor urban neighborhoods.The Journal of allergy and clinical immunology · 2023Article
- Percent Recovery Index Predicts Poor Asthma Control and Exacerbation in Adults.Journal of asthma and allergy · 2023Article
- Asthma with recurrent middle lobe syndrome in children: Clinical features and lung function patterns.Frontiers in pediatrics · 2023Article
- An a Priori Approach to Small Airway Dysfunction in Pediatric Asthmatics.Children (Basel, Switzerland) · 2022Article
- Lung Function Tests, Quality of Life and Telemedicine: Three Windows on the Multifaceted World of Asthma in Adolescents.Children (Basel, Switzerland) · 2022Review
- Peripheral airways involvement in children with asthma exacerbation.The clinical respiratory journal · 2022Article
- Small Airway Disease in Pediatric Asthma: the Who, What, When, Where, Why, and How to Remediate. A Review and Commentary.Clinical reviews in allergy & immunology · 2022Review
- Responsiveness to Parenteral Corticosteroids and Lung Function Trajectory in Adults with Moderate-to-Severe Asthma.American journal of respiratory and critical care medicine · 2021Article
- Heterogeneity of Childhood Asthma in Korea: Cluster Analysis of the Korean Childhood Asthma Study Cohort.Allergy, asthma & immunology research · 2021Article
- "Poor Effort" Does Not Account for Reduced Forced Vital Capacity in Asthmatic Children.Frontiers in pediatrics · 2021Article
- Disparate diagnostic accuracy of lung function tests as predictors of poor asthma control in children.The Journal of asthma : official journal of the Association for the Care of Asthma · 2020Observational
- Bronchodilator Dose Responsiveness in Children and Adolescents: Clinical Features and Association with Future Asthma Exacerbations.The journal of allergy and clinical immunology. In practice · 2020Article
- Compressive air trapping in asthma: effects of age, sex, and severity.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Asthma Endotyping and Biomarkers in Childhood Asthma.Pediatric allergy, immunology, and pulmonology · 2018Review
- Longitudinal association of adiposity with wheezing and atopy at 22 years: the 1993 Birth Cohort, Pelotas, Brazil.Journal of asthma and allergy · 2018Article
Corrections and comments
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Authors and funding
17 authors at 12 institutions in 1 country.
Funding
Abstract
backgroundSmall-airways instability resulting in premature airway closure has been recognized as a risk for asthma severity and poor control. Although spirometry has limited sensitivity for detecting small-airways dysfunction, a focus on the air-trapping component of obstruction might identify a risk factor for asthma instability.
objectiveWe sought to use spirometric measurements to identify patterns of airway obstruction in children and define obstruction phenotypes that relate to asthma instability.
methodsPrebronchodilation and postbronchodilation spirometric data were obtained from 560 children in the Asthma Phenotypes in the Inner City study. An air-trapping obstruction phenotype (A Trpg) was defined as a forced vital capacity (FVC) z score of less than -1.64 or an increase in FVC of 10% of predicted value or greater with bronchodilation. The airflow limitation phenotype (A Limit) had an FEV
resultsPatients with the A Trpg phenotype (14% of the cohort) had more exacerbations during the 12-month study compared with those with the A Limit (P < .03) and None (P < .001) phenotypes. Patients with the A Trpg phenotype also had the highest Composite Asthma Severity Index score, the highest asthma treatment step, the greatest variability in FEV
conclusionsA Trpg and A Limit patterns of obstruction, as defined by using routine spirometric measurements, can identify obstruction phenotypes that are indicators of risk for asthma severity and instability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.