ArticleJournal of the American Medical Directors Association2018
Joint Trajectories of Cognition and Frailty and Associated Burden of Patient-Reported Outcomes.
Article in Journal of the American Medical Directors Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Global Prevalence of Cognitive Frailty in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists · 2026Pooled it
- A Systematic Review of Frailty Trajectories: Their Shape and Influencing Factors.The Gerontologist · 2021Pooled it
- Gut microbiota, cognitive frailty and dementia in older individuals: a systematic review.Clinical interventions in aging · 2018Pooled it
- Effects of Combined Resistance and Power Training on Cognitive Function in Older Women: A Randomized Controlled Trial.International journal of environmental research and public health · 2020Trial
- Methodological Considerations in Interpreting Joint Trajectories of Frailty and Cognition in Older Koreans.Geriatrics & gerontology international · 2026Article
- Joint Trajectories of Frailty and Cognitive Function in Older Koreans Based on 14-Year Period Data From Korean Longitudinal Study of Aging (KLoSA).Geriatrics & gerontology international · 2026Article
- The impact of lifestyle factors on trajectories of cognitive subtypes in the older adult population.Scientific reports · 2025Article
- Delineating Life-Course Percentile Curves and Normative Values of Multi-Systemic Ageing Metrics in the United Kingdom, the United States, and China.Journal of cachexia, sarcopenia and muscle · 2025Article
- Multitrajectories of Frailty and Depression With Cognitive Function: Findings From the Health and Retirement Longitudinal Study.Journal of cachexia, sarcopenia and muscle · 2025Article
- Care Recipients' Cognitive Trajectories and Caregivers' Depressive Symptoms: The Mediating Role of Caregiving Burden.The Gerontologist · 2025Article
- Impact of Modifiable Factors Associated with Physical Frailty and Cognitive Impairment Trajectory of Older Adults: Using the Korean Longitudinal Study of Aging 2006-2018.Healthcare (Basel, Switzerland) · 2025Article
- Alcohol Use and Its Associations With Frailty, Fractures, and Falls Among Older Adults With HIV.Alcohol research : current reviews · 2025Review
- Prevalence and factors influencing disability and cognitive impairment among empty nesters and non-empty nesters in Guangdong, China: a cross-sectional study.Frontiers in public health · 2025Article
- Feasibility of In-Hospital Administration of a Tool to Predict Persistent Post-ICU Functional Impairment Among Older ICU Survivors: A Pilot Study.CHEST critical care · 2024Article
- Physical Health-Related Quality of Life and Postsurgical Outcomes in Brain Tumor Resection Patients.Asian journal of neurosurgery · 2024Article
- What patient-reported outcome measures may be suitable for research involving older adults with frailty? A scoping review.European geriatric medicine · 2024Article
- Leveraging Health Services Research to Address Aging Health Equity.Generations (San Francisco, Calif.) · 2024Article
- Exploring the association between multidimensional social isolation and heterogeneous cognitive trajectories among older adults: evidence from China.Frontiers in public health · 2024Article
- Association between disability and cognitive function in older Chinese people: a moderated mediation of social relationships and depressive symptoms.Frontiers in public health · 2024Article
- Trajectories of cognitive function and frailty in older adults in China: a longitudinal study.Frontiers in aging neuroscience · 2024Article
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Authors and funding
5 authors.
Funding
Abstract
objectivesTo evaluate joint trajectories of cognition and frailty and their association with the cumulative burden of patient-reported outcomes, including hospitalization, nursing home admission, and disability.
designLongitudinal study of 754 community-living persons aged 70 or older.
participants690 participants who had a baseline and at least one follow-up assessment of cognition and frailty between 1998 and 2009. MEASUREMENTS: Cognition was assessed using the Mini-Mental State Examination (MMSE). Frailty was defined by the 5 criteria for the Fried phenotype: muscle weakness, exhaustion, low physical activity, shrinking, and slow walking speed. A group-based, mixture modeling approach was used to fit the joint trajectories of cognition and frailty. The cumulative burden of hospitalization, nursing home admission, and disability over 141 months associated with the joint trajectories was evaluated using a series of generalized estimating equation Poisson models.
resultsFour joint trajectories were identified, including No cognitive frailty (27.8%), Slow cognitive decline and progressive frailty (45.5%), Rapid cognitive decline and progressive frailty (20.2%), and Cognitive frailty (6.5%). For each joint trajectory group, the interval-specific incidence density rates of all patient-reported outcomes tended to increase over time, with the exception of hospitalization for which the increasing trend was apparent only for the Slow cognitive decline and progressive frailty group. The No cognitive frailty group had the lowest cumulative burden of all patient-reported outcomes [eg, nursing home admissions, 7.5/1000 person-months, 95% confidence interval (CI): 4.8-11.7], whereas the Cognitive frailty group had the highest cumulative burden (eg, nursing home admissions, 381.1/1000 person-months, 95% CI: 294.5-493.1), with the exception of hospitalization. Compared with the No cognitive frailty group, the 3 other joint trajectory groups all had significantly greater burden of the patient-reported outcomes.
conclusionCommunity-living older persons exhibit distinct joint trajectories of cognition and frailty and experience an increasing burden of nursing home admission and disability as they age, with the greatest burden for those on a cognitive frailty trajectory.
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