Evidence map›Paper›PMID 29145866›Full record

ArticleStem cell research & therapy2017

Calcium-containing scaffolds induce bone regeneration by regulating mesenchymal stem cell differentiation and migration.

Rubén Aquino-Martínez, Alcira P Angelo, Francesc Ventura Pujol

Open access · goldAbstract read
In one paragraph

Article in Stem cell research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 72 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Rubén Aquino-MartínezDepartament de Ciències Fisiològiques, Universitat de Barcelona, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Alcira P AngeloDepartament de Ciències Fisiològiques, Universitat de Barcelona, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Francesc Ventura PujolDepartament de Ciències Fisiològiques, Universitat de Barcelona, IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain. fventura@ub.edu.ORCID http://orcid.org/0000-0001-9673-9405
Bellvitge University Hospital · ESInstitut d'Investigació Biomédica de Bellvitge · ESMayo Clinic · US

Funding

MICINN BFU 2014-56313
6 · The paper itself

Abstract

backgroundOsteoinduction and subsequent bone formation rely on efficient mesenchymal stem cell (MSC) recruitment. It is also known that migration is induced by gradients of growth factors and cytokines. Degradation of Ca

methodsA circular calvarial bone defect (5 mm diameter) was created in the parietal bone of 35 Balb-C mice. We prepared and implanted a cell-free agarose/gelatin scaffold alone or in combination with different CaSO

resultsCaSO

conclusionsSpecific CaSO

Indexed as

Tissue ScaffoldsAndrostadienesAnimalsBone Morphogenetic Protein 2Bone RegenerationCalcium SulfateCell DifferentiationCell MovementChromonesGelatinGene Expression RegulationMaleMesenchymal Stem CellsMiceMice, Inbred BALB CMorpholines2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneAndrostadienesBmp2 protein, mouseBone Morphogenetic Protein 2Calcium SulfateChromonesGelatinMorpholinesPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSepharoseWortmanninBone graftsBone morphogenetic proteinBone regenerationBone remodelingCalcium sulfateCraniofacialMesenchymal stem cellsMigrationOsteoinduction

Identifiers

PMID29145866
PMCPMC5689169
OpenAlexW2768220377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.