ArticleBMC complementary and alternative medicine2017
Molecular network-based analysis of the mechanism of liver injury induced by volatile oils from Artemisiae argyi folium.
Article in BMC complementary and alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 13 citations in OpenAlex.
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- Late-life plasma proteins associated with prevalent and incident frailty: A proteomic analysis.Aging cell · 2023Article
- Immune-mediated herb-induced liver injury: a potential association with herbal artemisinin use as supported by the updated RUCAM.BMJ case reports · 2023Article
- Deciphering the toxicity-effect relationship and action patterns of traditional Chinese medicines from a smart data perspective: a comprehensive review.Frontiers in pharmacology · 2023Review
- Danger of Herbal Tea: A Case of Acute Cholestatic Hepatitis Due toFrontiers in medicine · 2019Article
- Unraveling the action mechanism ofAmerican journal of translational research · 2019Article
- Uncovering the action mechanism of polydatinRSC advances · 2018Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundVolatile oils from Artemisiae argyi folium (VOAAF) is reported with hepatotoxicity, but the underlying mechanism is still unclear.
methodsIn the present study this molecular mechanism was explored with the Ingenuity Pathway Analysis (IPA). The chemical components of the VOAAF were searched in the database, and their target proteins were all identified in the PubChem, while drug-induced liver injury (DILI) genes were searched in the PubMed gene databases. The molecular network of protein targets for VOAAF and DILI genes was built with the IPA. The canonical pathways between the 2 networks were compared to decipher the molecular mechanisms of the liver injury induced by VOAAF.
resultsThere were 159 target proteins for VOAAF and 338 genes related to DILI identified, which were further analyzed in the IPA. The canonical pathway comparison showed that VOAAF and DILI both worked on aryl hydrocarbon receptor (AHR), lipopolysaccharide (LPS)/interleukin 1 (IL-1) mediated inhibition of retinoid X receptor (RXR) function, pregnane X receptor (PXR)/RXR activation, xenobiotic metabolism, peroxisome proliferator-activated receptor (PPAR), hepatic cholestasis, farnesoid X receptor (FXR)/RXR activation, and glucocorticoid receptor.
conclusionVOAAF-induced liver injury may be involved in many pathways in which the AHR signaling and LPS/IL-1 mediated inhibition of RXR function pathways could be the most vital.
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