Evidence map›Paper›PMID 29145781›Full record

ArticleToxicologic pathology2018

Analytical High-resolution Electron Microscopy Reveals Organ-specific Nanoceria Bioprocessing.

Uschi M Graham, Robert A Yokel, Alan K Dozier, Lawrence Drummy, Krishnamurthy Mahalingam, Michael T Tseng, Eileen Birch, Joseph Fernback

Open access · bronzeAbstract read
In one paragraph

Article in Toxicologic pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
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  4. Review
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  8. Cerium Oxide Nanoparticles Alleviate Hepatic Fibrosis Phenotypes In Vitro.International journal of molecular sciences · 2021
    Article
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  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Uschi M Graham1 Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky Academic Medical Center, Lexington, Kentucky, USA.
Robert A Yokel1 Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky Academic Medical Center, Lexington, Kentucky, USA.
Alan K Dozier2 National Institute of Occupational Safety and Health, Cincinnati, Ohio, USA.
Lawrence Drummy3 U.S. Air Force Research Laboratory, Dayton, Ohio, USA.
Krishnamurthy Mahalingam3 U.S. Air Force Research Laboratory, Dayton, Ohio, USA.
Michael T Tseng4 Department of Anatomical Sciences and Neurobiology, College of Medicine, University of Louisville, Louisville, Kentucky, USA.
Eileen Birch2 National Institute of Occupational Safety and Health, Cincinnati, Ohio, USA.
Joseph Fernback2 National Institute of Occupational Safety and Health, Cincinnati, Ohio, USA.
National Institute for Occupational Safety and Health · USUnited States Air Force Research Laboratory · USUniversity of Kentucky · USUniversity of Louisville · US

Funding

Reconciling Nanoceria's Jekyll and Hyde Reputation Toward Safer NanotherapyR01GM109195 · NIGMS · UNIVERSITY OF KENTUCKY · PI YOKEL, ROBERT ALLEN · 2015 to 2018
$1.3M
NIGMS NIH HHS R01 GM109195
6 · The paper itself

Abstract

This is the first utilization of advanced analytical electron microscopy methods, including high-resolution transmission electron microscopy, high-angle annular dark field scanning transmission electron microscopy, electron energy loss spectroscopy, and energy-dispersive X-ray spectroscopy mapping to characterize the organ-specific bioprocessing of a relatively inert nanomaterial (nanoceria). Liver and spleen samples from rats given a single intravenous infusion of nanoceria were obtained after prolonged (90 days) in vivo exposure. These advanced analytical electron microscopy methods were applied to elucidate the organ-specific cellular and subcellular fate of nanoceria after its uptake. Nanoceria is bioprocessed differently in the spleen than in the liver.

Indexed as

AnimalsCeriumLiverMaleMicroscopy, ElectronRatsRats, Sprague-DawleySpleenceric oxideCeriumbioprocessingionslivernanoceriananoparticlesspleentransformation

Identifiers

PMID29145781
PMCPMC5954437
OpenAlexW2769861469

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.