ArticlePLoS pathogens2017
Preconceptual Zika virus asymptomatic infection protects against secondary prenatal infection.
Article in PLoS pathogens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 23 citations in OpenAlex.
- Epidemic Comparison of Ebola and Zika-the Only Two Neglected Tropical Diseases with Vertical Transmission Potential and Associated with Public Health Emergency of International Concern-among Childbearing Women.International journal of women's health · 2026Article
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- Current State ofFoods (Basel, Switzerland) · 2021Review
- Vertical transmission of Zika virus and its outcomes: a Bayesian synthesis of prospective studies.The Lancet. Infectious diseases · 2021Article
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- Nano-based approaches in the development of antiviral agents and vaccines.Life sciences · 2021Review
- The Neurobiology of Zika Virus: New Models, New Challenges.Frontiers in neuroscience · 2021Review
- Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis.Journal of medical virology · 2020Article
- Persistent Zika Virus Clinical Susceptibility despite Reduced Viral Burden in Mice with Expanded Virus-Specific CD8Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Rapid Detection of IgM Antibodies against the SARS-CoV-2 Virus via Colloidal Gold Nanoparticle-Based Lateral-Flow Assay.ACS omega · 2020Article
- Long-Term Protection of Rhesus Macaques from Zika Virus Reinfection.Journal of virology · 2020Article
- Article
- Article
- Commensal Candida albicans Positively Calibrates Systemic Th17 Immunological Responses.Cell host & microbe · 2019Article
- Persistence of Zika Virus in Body Fluids - Final Report.The New England journal of medicine · 2019Article
- Transfusion-Transmitted Zika Virus Infection in Pregnant Mice Leads to Broad Tissue Tropism With Severe Placental Damage and Fetal Demise.Frontiers in microbiology · 2019Article
- CD4+ T cells promote humoral immunity and viral control during Zika virus infection.PLoS pathogens · 2019Article
- Animal Models of Zika Virus Infection during Pregnancy.Viruses · 2018Review
- Cellular and Humoral Immunity Protect against Vaginal Zika Virus Infection in Mice.Journal of virology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
Abstract
Pregnant women, and their fetal offspring, are uniquely susceptible to Zika virus and other microbial pathogens capable of congenital fetal infection. Unavoidable exposure to Zika virus in endemic areas underscores the need for identifying at-risk individuals, and protecting expecting mothers and their fetal offspring against prenatal infection. Here we show that primary Zika virus asymptomatic infection in mice confers protection against re-infection, and that these protective benefits are maintained during pregnancy. Zika virus recovery was sharply reduced in maternal tissues and amongst fetal concepti after prenatal challenge in mothers with resolved subclinical infection prior to pregnancy compared with mice undergoing primary prenatal infection. These benefits coincide with expanded accumulation of viral-specific antibodies in maternal serum and fetal tissues that protect against infection by the identical or heterologous Zika virus genotype strains. Thus, preconceptual infection primes Zika virus-specific antibodies that confer cross-genotype protection against re-infection during pregnancy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.