ArticlePloS one2017
Abnormal brain white matter microstructure is associated with both pre-hypertension and hypertension.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 56 citations in OpenAlex.
- Tissue-specific diffusion abnormalities and localized free-water reductions in hypertension despite no detectable group difference in the DTI-ALPS index.Frontiers in medicine · 2026Article
- Blood pressure and the brain: the conundrum of hypertension and dementia.Cardiovascular research · 2025Review
- Lifespan cardiometabolic exposures are associated with midlife white matter microstructure: The Bogalusa Heart Study.NeuroImage · 2025Article
- Alcohol, smoking, and brain structure: common or substance specific associations.medRxiv : the preprint server for health sciences · 2024Article
- Integrating external summary information in the presence of prior probability shift: an application to assessing essential hypertension.Biometrics · 2024Article
- Association between household size and risk of incident dementia in the UK Biobank study.Scientific reports · 2024Article
- Effect of the duration of hypertension on white matter structure and its link with cognition.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Impaired mobility and MRI markers of vascular brain injury: Atherosclerosis Risk in Communities and UK Biobank studies.BMJ neurology open · 2024Article
- Deciphering the causal relationship between blood pressure and regional white matter integrity: A two-sample Mendelian randomization study.Journal of neuroscience research · 2023Article
- Topography of associations between cardiovascular risk factors and myelin loss in the ageing human brain.Communications biology · 2023Article
- Association of Early Adulthood Hypertension and Blood Pressure Change With Late-Life Neuroimaging Biomarkers.JAMA network open · 2023Article
- White matter changes underlie hypertension-related cognitive decline in older adults.NeuroImage. Clinical · 2023Review
- Multi-organ imaging demonstrates the heart-brain-liver axis in UK Biobank participants.Nature communications · 2022Article
- Comparison of Diffusion Tensor Imaging Metrics in Normal-Appearing White Matter to Cerebrovascular Lesions and Correlation with Cerebrovascular Disease Risk Factors and Severity.International journal of biomedical imaging · 2022Article
- Vascular and microstructural markers of cognitive pathology.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Signal complexity indicators of health status in clinical EEG.Scientific reports · 2021Article
- Neurovascular dysfunctions in hypertensive disorders of pregnancy.Metabolic brain disease · 2021Review
- Neurite orientation dispersion and density imaging reveals white matter microstructural alterations in adults with autism.Molecular autism · 2021Article
- Observational
- Age and Sex Differences in the Associations of Pulse Pressure With White Matter and Subcortical Microstructure.Hypertension (Dallas, Tex. : 1979) · 2021Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesTo characterize effects of chronically elevated blood pressure on the brain, we tested for brain white matter microstructural differences associated with normotension, pre-hypertension and hypertension in recently available brain magnetic resonance imaging data from 4659 participants without known neurological or psychiatric disease (62.3±7.4 yrs, 47.0% male) in UK Biobank.
methodsFor assessment of white matter microstructure, we used measures derived from neurite orientation dispersion and density imaging (NODDI) including the intracellular volume fraction (an estimate of neurite density) and isotropic volume fraction (an index of the relative extra-cellular water diffusion). To estimate differences associated specifically with blood pressure, we applied propensity score matching based on age, sex, educational level, body mass index, and history of smoking, diabetes mellitus and cardiovascular disease to perform separate contrasts of non-hypertensive (normotensive or pre-hypertensive, N = 2332) and hypertensive (N = 2337) individuals and of normotensive (N = 741) and pre-hypertensive (N = 1581) individuals (p<0.05 after Bonferroni correction).
resultsThe brain white matter intracellular volume fraction was significantly lower, and isotropic volume fraction was higher in hypertensive relative to non-hypertensive individuals (N = 1559, each). The white matter isotropic volume fraction also was higher in pre-hypertensive than in normotensive individuals (N = 694, each) in the right superior longitudinal fasciculus and the right superior thalamic radiation, where the lower intracellular volume fraction was observed in the hypertensives relative to the non-hypertensive group. SIGNIFICANCE: Pathological processes associated with chronically elevated blood pressure are associated with imaging differences suggesting chronic alterations of white matter axonal structure that may affect cognitive functions even with pre-hypertension.
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