ReviewNeuron2017
Orbitofrontal Cortex: A Neural Circuit for Economic Decisions.
Review in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
146 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of reward processing in major depressive disorder reveals distinct abnormalities within the reward circuit.Translational psychiatry · 2019Pooled it
- Comparative effects of resistance- and assistance-based robot training on brain activation and motor recovery in stroke patients.Frontiers in neurologyTrial
- Laminar architecture of a decision circuit in the mouse orbitofrontal cortex.Nature communications · 2026Article
- Wanting this, not that: The neural circuit that turns specific expectations into actions.PLoS biology · 2026Article
- A corticostriatal circuit updates subjective beliefs about latent task states.bioRxiv : the preprint server for biology · 2026Article
- Prefrontal modulation of striatal engagement: a hierarchical framework for goal-directed behavior.Communications biology · 2026Review
- Effort and its perception revisited: How physical-domain insights could lead toward a unified theory.Cognitive, affective & behavioral neuroscience · 2026Review
- Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Self-allocation bias in performance-based cooperative decisions is driven by self-interest rather than distorted performance encoding.PLoS biology · 2026Article
- Dopaminergic responses to identity prediction errors depend differently on the orbitofrontal cortex and hippocampus.Behavioral neuroscience · 2026Article
- Temporal-oscillatory entrainment: a multi-timescale framework for rhythmic coordination from neural to social frequencies.Frontiers in human neuroscience · 2026Article
- Time-Dependent Therapeutic Effect of S-Ketamine on PTSD Mediated by VTA-OFC Dopaminergic Neurocircuit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A neural circuit framework for economic choice: from building blocks of valuation to compositionality in multitasking.bioRxiv : the preprint server for biology · 2025Article
- Group membership and stereotype content jointly affect neural processing during resource allocation decisions.Scientific reports · 2025Article
- Sparse memory ensembles set brain-wide network states to sustain learned associations.iScience · 2025Article
- Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk.bioRxiv : the preprint server for biology · 2025Article
- Article
- Compare first, evaluate later: Upending the neuroscience of choice.PLoS biology · 2025Article
- Orbitofrontal cortex computes gaze-dependent comparisons between attributes rather than integrated values.PLoS biology · 2025Article
86 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Economic choice behavior entails the computation and comparison of subjective values. A central contribution of neuroeconomics has been to show that subjective values are represented explicitly at the neuronal level. With this result at hand, the field has increasingly focused on the difficult question of where in the brain and how exactly subjective values are compared to make a decision. Here, we review a broad range of experimental and theoretical results suggesting that good-based decisions are generated in a neural circuit within the orbitofrontal cortex (OFC). The main lines of evidence supporting this proposal include the fact that goal-directed behavior is specifically disrupted by OFC lesions, the fact that different groups of neurons in this area encode the input and the output of the decision process, the fact that activity fluctuations in each of these cell groups correlate with choice variability, and the fact that these groups of neurons are computationally sufficient to generate decisions. Results from other brain regions are consistent with the idea that good-based decisions take place in OFC and indicate that value signals inform a variety of mental functions. We also contrast the present proposal with other leading models for the neural mechanisms of economic decisions. Finally, we indicate open questions and suggest possible directions for future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.