Evidence map›Paper›PMID 29144833›Full record

ArticleGut microbes2018

Low dietary fiber intake increases Collinsella abundance in the gut microbiota of overweight and obese pregnant women.

Luisa F Gomez-Arango, Helen L Barrett, Shelley A Wilkinson, Leonie K Callaway, H David McIntyre, Mark Morrison, Marloes Dekker Nitert

Open access · goldAbstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 254 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
254citing papers in PubMed, 11 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

254 citing papers in PubMed, 11 syntheses or guidelines pooled it, 387 citations in OpenAlex.

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194 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Luisa F Gomez-Arangoa UQ Centre for Clinical Research, The University of Queensland , Brisbane , Australia.
Helen L Barretta UQ Centre for Clinical Research, The University of Queensland , Brisbane , Australia.
Shelley A Wilkinsond Mater Health Services, Nutrition and Dietetics, Mater Hospital , Brisbane , Australia.
Leonie K Callawaya UQ Centre for Clinical Research, The University of Queensland , Brisbane , Australia.
H David McIntyreb Faculty of Medicine, The University of Queensland , Brisbane , Australia.
Mark Morrisonb Faculty of Medicine, The University of Queensland , Brisbane , Australia.
Marloes Dekker Niterta UQ Centre for Clinical Research, The University of Queensland , Brisbane , Australia.
University of Queensland · AUMater Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota contributes to the regulation of glucose metabolism in pregnancy. Abundance of the genus Collinsella is positively correlated with circulating insulin; however, it is unclear what determines Collinsella abundance. This study aims to validate the correlation between Collinsella and insulin and to elucidate if macronutrient intake alters Collinsella abundance and gut microbiota composition. Gut microbiota profiles were assessed by 16S rRNA sequencing in 57 overweight and 73 obese pregnant women from the SPRING (Study of PRobiotics IN Gestational diabetes) trial at 16 weeks gestation and correlated with metabolic hormone levels and macronutrient intake. Gut microbiota composition in the top and bottom 10% of dietary fiber intake was evaluated through network analysis. Collinsella abundance correlated positively with circulating insulin (rho = 0.30, p = 0.0006), independent of maternal BMI, but negatively with dietary fiber intake (rho = -0.20, p = 0.025) in this cohort. Low dietary fiber intake was associated with a gut microbiota favoring lactate fermentation while high fiber intake promotes short-chain fatty acid-producing bacteria. Low dietary fiber may enable overgrowth of Collinsella and alter the overall fermentation pattern in gut microbiota. This suggests that dietary choices during pregnancy can modify the nutritional ecology of the gut microbiota, with potential deleterious effects on the metabolic and inflammatory health of the host.

trial registrationANZCTR 12611001208998, registered 23/11/2011.

Indexed as

ActinobacteriaAdultBacteriaCohort StudiesDietary FiberDNA, BacterialFatty Acids, VolatileFecesFemaleGastrointestinal MicrobiomeGestational AgeHumansInsulinObesityOverweightPregnancyDietary FiberDNA, BacterialFatty Acids, VolatileInsulinRNA, Ribosomal, 16SCollinsellaFiber and ObesityInsulinMicrobiotaPregnancy

Identifiers

PMID29144833
PMCPMC6219589
OpenAlexW2768282074

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.