Evidence map›Paper›PMID 29144584›Full record

ArticleMacromolecular bioscience2017

3D Printed Anchoring Sutures for Permanent Shaping of Tissues.

Wei Wei, Yuxiao Li, Huazhe Yang, Reza Nassab, Fatemeh Shahriyari, Ali Akpek, Xiaofei Guan, Yanhui Liu, Shahrouz Taranejoo, Ali Tamayol and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular bioscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wei WeiDivision of Engineering in Medicine, Department of Medicine, Biomaterials Innovation Research Center, Brigham & Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Yuxiao LiDivision of Engineering in Medicine, Department of Medicine, Biomaterials Innovation Research Center, Brigham & Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Huazhe YangDivision of Engineering in Medicine, Department of Medicine, Biomaterials Innovation Research Center, Brigham & Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Reza NassabThe Wilmslow Hospital, Wilmslow, Cheshire, SK9 1NY GB, UK.
Fatemeh ShahriyariDivision of Engineering in Medicine, Department of Medicine, Biomaterials Innovation Research Center, Brigham & Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Ali AkpekDivision of Engineering in Medicine, Department of Medicine, Biomaterials Innovation Research Center, Brigham & Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Xiaofei GuanDivision of Engineering in Medicine, Department of Medicine, Biomaterials Innovation Research Center, Brigham & Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Yanhui LiuDivision of Engineering in Medicine, Department of Medicine, Biomaterials Innovation Research Center, Brigham & Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Shahrouz TaranejooDivision of Engineering in Medicine, Department of Medicine, Biomaterials Innovation Research Center, Brigham & Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Ali TamayolDivision of Engineering in Medicine, Department of Medicine, Biomaterials Innovation Research Center, Brigham & Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Yu Shrike ZhangDivision of Engineering in Medicine, Department of Medicine, Biomaterials Innovation Research Center, Brigham & Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Ali KhademhosseiniDivision of Engineering in Medicine, Department of Medicine, Biomaterials Innovation Research Center, Brigham & Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.
Hae Lin JangDivision of Engineering in Medicine, Department of Medicine, Biomaterials Innovation Research Center, Brigham & Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.ORCID 0000-0003-3923-9732

Funding

Microengineered Osteons for Bone Tissue EngineeringR01AR057837 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI YANG, YUNZHI · 2010 to 2018
$5.1M
Whitlockite nanoparticles for inducing bone regenerationR21AR070647 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KHADEMHOSSEINI, ALI · 2016 to 2017
$423k
NIAMS NIH HHS R01 AR057837NIAMS NIH HHS R21 AR070647
6 · The paper itself

Abstract

Sutures are one of the most widely used devices for adhering separated tissues after injury or surgery. However, most sutures require knotting, which can create a risk of inflammation, and can act as mechanically weak points that often result in breakage and slipping. Here, an anchoring suture is presented with a design that facilitates its propagation parallel to the suturing direction, while maximizing its resistive force against the opposite direction of external force to lock its position in tissues. Different microstructures of suture anchors are systematically designed using orthogonal arrays, and selected based on shape factors associated with mechanical strength. 3D printing is used to fabricate different types of hollow microstructured suture anchors, and optimize their structure for the effective shaping of tissues. To define the structural design for fixing tissues, the maximum force required to pull 3D printed anchors in different directions is examined with tissues. The tissue reshaping function of suture anchors is further simulated ex vivo by using swine ear, nose, and skin, and bovine muscle tendon. This study provides advantages for building functional sutures that can be used for permanently reshaping tissues with enhanced mechanical strength, eliminating the need for knotting to improve surgical efficiency.

Indexed as

Printing, Three-DimensionalSuturesAnimalsBiomechanical PhenomenaCells, CulturedComputer-Aided DesignEarHumansMaterials TestingMesenchymal Stem CellsNosePlastic Surgery ProceduresSwine3D printinganchoring sutureminimally invasive treatmentreconstructive surgerytissue reshaping

Identifiers

PMID29144584
PMCPMC5932114

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.