Evidence map›Paper›PMID 29144467›Full record

ReviewNature2017

Progress in and promise of bacterial quorum sensing research.

Marvin Whiteley, Stephen P Diggle, E Peter Greenberg

Erratum issuedAbstract readReview
In one paragraph

Review in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 508 papers.

0numbers the graph read from it
0cells of the map it votes in
508citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

508 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. α-Mangostin attenuatesVirulence · 2026
    Article
  5. MrtR ofProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Characterization of a Novel Quorum QuencherPlants (Basel, Switzerland) · 2026
    Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

448 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Marvin WhiteleySchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332-0230, USA.
Stephen P DiggleSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia 30332-0230, USA.
E Peter GreenbergDepartment of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-7735, USA.

Funding

Translational Research Center to Expedite Novel Therapies in Cystic FibrosisP30DK089507 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI Christopher Hooper Goss · 2010 to 2026
$21.4M
QUORUM SENSING IN PSEUDOMONAS AERUGINOSAR01GM059026 · NIGMS · UNIVERSITY OF WASHINGTON · PI GREENBERG, EVERETT P · 1999 to 2019
$6.5M
Probing Polymicrobial Synergy Using hihg Throughout GenomicsR01DE023193 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI LAMONT, RICHARD J, WHITELEY, MARVIN · 2013 to 2023
$4.7M
Metabolite sensing in a polymicrobial infectionR01DE020100 · NIDCR · UNIVERSITY OF TEXAS AT AUSTIN · PI WHITELEY, MARVIN · 2011 to 2022
$3.3M
Mechanisms of Pseudomonas aeruginosa virulence in polymicrobial wound infectionsR01GM116547 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI WHITELEY, MARVIN · 2016 to 2019
$1.2M
NIDCR NIH HHS R01 DE020100NIDCR NIH HHS R01 DE023193NIDDK NIH HHS P30 DK089507NIGMS NIH HHS R01 GM059026NIGMS NIH HHS R01 GM116547
6 · The paper itself

Abstract

This Review highlights how we can build upon the relatively new and rapidly developing field of research into bacterial quorum sensing (QS). We now have a depth of knowledge about how bacteria use QS signals to communicate with each other and to coordinate their activities. In recent years there have been extraordinary advances in our understanding of the genetics, genomics, biochemistry, and signal diversity of QS. We are beginning to understand the connections between QS and bacterial sociality. This foundation places us at the beginning of a new era in which researchers will be able to work towards new medicines to treat devastating infectious diseases, and use bacteria to understand the biology of sociality.

Indexed as

BacteriaQuorum SensingResearchAnimalsBacterial InfectionsBiofilmsEcosystemHumansPhylogeography

Identifiers

PMID29144467
PMCPMC5870893

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.