ArticleMolecules (Basel, Switzerland)2017
DNA G-Wire Formation Using an Artificial Peptide is Controlled by Protease Activity.
Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Development of MnInternational journal of molecular sciences · 2023Article
- Elemental composition control of gold-titania nanocomposites by site-specific mineralization using artificial peptides and DNA.Communications chemistry · 2021Article
- Article
- GC ends control topology of DNA G-quadruplexes and their cation-dependent assembly.Nucleic acids research · 2020Article
- Polymorphism of G4 associates: from stacks to wires via interlocks.Nucleic acids research · 2018Article
- Special Issue: Molecular Properties and the Applications of Peptide Nucleic Acids.Molecules (Basel, Switzerland) · 2018Article
- High-resolution AFM structure of DNA G-wires in aqueous solution.Nature communications · 2018Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of a switching system for guanine nanowire (G-wire) formation by external signals is important for nanobiotechnological applications. Here, we demonstrate a DNA nanostructural switch (G-wire <--> particles) using a designed peptide and a protease. The peptide consists of a PNA sequence for inducing DNA to form DNA-PNA hybrid G-quadruplex structures, and a protease substrate sequence acting as a switching module that is dependent on the activity of a particular protease. Micro-scale analyses via TEM and AFM showed that G-rich DNA alone forms G-wires in the presence of Ca
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