ArticleThe Journal of physiology2018
Sustained cardiac programming by short-term juvenile exercise training in male rats.
Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Age-dependent effects of aerobic training on cardiac expression of Akt1, mTOR, and CITED4 in immature, young-adult, and middle-aged rat myocardium.European journal of applied physiology · 2026Article
- Metformin and insulin exacerbate one-carbon metabolism deficits in pregnant growth restricted rats and impacts the placenta, fetal liver and pancreas.The Journal of physiology · 2025Article
- Skeletal Muscle Mitochondria Contain Nuclear-Encoded RNA Species Prior to and Following Adaptation to Exercise Training in Rats.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Scaling of quantitative cardiomyocyte properties in the left ventricle of different mammalian species.The Journal of experimental biology · 2025Article
- Human platelet lysate combined with mesenchymal stem cells pretreated with platelet lysate improved cardiac function in rats with myocardial infarction.Scientific reports · 2024Article
- Intrinsic and Extrinsic Contributors to the Cardiac Benefits of Exercise.JACC. Basic to translational science · 2024Review
- Juvenile physical activity protects against isoproterenol-induced cardiac dysfunction later in life.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Review
- EFFECT OF AEROBIC AND ANAEROBIC TRAINING ON DIFFERENT ERGOMETERS IN RAT MUSCLE AND HEART TISSUES.Acta ortopedica brasileira · 2022Article
- Sex-Specific Impacts of Exercise on Cardiovascular Remodeling.Journal of clinical medicine · 2021Review
- Targets identified from exercised heart: killing multiple birds with one stone.NPJ Regenerative medicine · 2021Review
- Cardiac Effects of Treadmill Running at Different Intensities in a Rat Model.Frontiers in physiology · 2021Article
- Exercise initiated during pregnancy in rats born growth restricted alters placental mTOR and nutrient transporter expression.The Journal of physiology · 2019Article
- Maternal exercise in rats upregulates the placental insulin-like growth factor system with diet- and sex-specific responses: minimal effects in mothers born growth restricted.The Journal of physiology · 2018Article
- Programming repercussions of early life training exercise on the heart.The Journal of physiology · 2018Article
- Early exercise for lifelong benefit: sustained cardiac programming in rats and the potential translation to humans.The Journal of physiology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key pointsCardiac hypertrophy following endurance-training is thought to be due to hypertrophy of existing cardiomyocytes. The benefits of endurance exercise on cardiac hypertrophy are generally thought to be short-lived and regress to sedentary levels within a few weeks of stopping endurance training. We have now established that cardiomyocyte hyperplasia also plays a considerable role in cardiac growth in response to just 4 weeks of endurance exercise in juvenile (5-9 weeks of age) rats. The effect of endurance exercise on cardiomyocyte hyperplasia diminishes with age and is lost by adulthood. We have also established that the effect of juvenile exercise on heart mass is sustained into adulthood. ABSTRACT: The aim of this study was to investigate if endurance training during juvenile life 'reprogrammes' the heart and leads to sustained improvements in the structure, function, and morphology of the adult heart. Male Wistar Kyoto rats were exercise trained 5 days week
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