ArticleJournal of cancer research and clinical oncology2018
Head and neck rhabdomyosarcoma in children: a 20-year retrospective study at a tertiary referral center.
Article in Journal of cancer research and clinical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Therapeutic outcome and prognostic factors in sinonasal rhabdomyosarcoma: a single-institution case series.Journal of cancer research and clinical oncology · 2019Trial
- Pediatric head and neck sarcomas: a retrospective study from a national tertiary referral center.European journal of pediatrics · 2025Article
- Rhabdomyosarcoma of the Middle Ear Case Report.Children (Basel, Switzerland) · 2024Article
- Ocular manifestations and long-term complications of rhabdomyosarcoma in children.Eye (London, England) · 2024Observational
- A 16-Year-Old Girl with Sinonasal Cutaneous Fistula Following Excision and Radiotherapy for Rhabdomyosarcoma Requiring Reconstructive Surgery Using an Expanded Forehead Flap.The American journal of case reports · 2024Article
- Rhabdomyosarcoma with TFCP2 Rearrangement or Typical Co-expression of AE1/AE3 and ALK: Report of Three New Cases in the Head and Neck Region and Literature Review.Head and neck pathology · 2023Review
- Clinical-pathologic profile of head and neck rhabdomyosarcoma in children: a systematic review.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2023Review
- Patient-reported outcomes in childhood head and neck rhabdomyosarcoma survivors and their relation to physician-graded adverse events-A multicenter study using the FACE-Q Craniofacial module.Cancer medicine · 2023Article
- Review
- When a stuffy nose won't go away: Rhabdomyosarcoma masquerading as adenoiditis.Radiology case reports · 2021Article
- Article
- Modified Gap Arthroplasty for Temporomandibular Joint Ankylosis Following Radiotherapy for Rhabdomyosarcoma: Report of an Unusual Case and Brief Literature Review.Frontiers in oncology · 2021Article
- Locoregional Control and Survival in Children, Adolescents, and Young Adults With Localized Head and Neck Alveolar Rhabdomyosarcoma-The French Experience.Frontiers in pediatrics · 2021Article
- Pediatric sinonasal and skull base lesions.World journal of otorhinolaryngology - head and neck surgery · 2020Review
- Extranodal NK/T-cell lymphoma in adolescents: imaging findings of a consecutive 7-year case series.The Journal of international medical research · 2019Article
- Rhabdomyosarcoma.Nature reviews. Disease primers · 2019Review
- Congenital Rhabdomyosarcoma Presenting as a Neck Mass at Birth.Case reports in pediatrics · 2018Article
- [Imaging of orbital tumors in children].The Pan African medical journal · 2018Article
- Rare Presentations of Embryonal Rhabdomyosarcoma in the Middle Ear of a 3-Year-Old Boy and Girl.Nigerian medical journal : journal of the Nigeria Medical AssociationArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of this study was to assess rhabdomyosarcomas (RMS) of the head and neck in pediatric patients with regard to clinical presentation, treatment, and survival.
methodsData were retrospectively obtained from patient charts with regard to RMS of the head and neck diagnosed between 1996 and 2016 at a tertiary referral center. Clinical course, treatment modalities, and side effects were analyzed. Survival analysis was carried out using the Kaplan-Meier method.
resultsTwenty-eight patients (17 male, 11 female) with a mean age at diagnosis of 6.8 ± 5.0 years have been included. Fourteen patients (50%) presented with painless swelling in the head and neck region and nine patients (32.1%) presented with cranial nerve deficit at initial diagnosis. The location of the majority of rhabdomyosarcomas was orbital (N = 9; 32.1%), followed by parapharyngeal (n = 4; 14.2%) and sinonasal (n = 3; 10.7%). All patients (n = 28; 100%) received polychemotherapy, additional adjuvant radiation therapy was carried out in 24 patients (85.7%), and surgery was performed in 12 cases (42.9%). The 5-year overall survival was 91.3%, and median progression-free survival was 46 ± 67.4 months. Common side effects resulting from chemotherapy and radiation therapy included neutropenia, mucositis, nausea and vomiting, and radiodermatitis, long-term side effects included microsomia and facial mutilation.
conclusionMultimodality treatment of rhabdomyosarcomas of the head and neck in pediatric patients may lead to a 5-year overall survival of up to 91.3%.
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