ArticleNature2017
Salt-responsive gut commensal modulates T
2 registry-linked trialsOpen access · greenAbstract read
In one paragraph
Article in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 757 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
757citing papers in PubMed, 6 pooled it
41.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Increased Salt Intake on Metabolic, Cardiovascular and Immunoregulatory Functions in Healthy Men
Effect of Probiotics on Grade 1 Primary Hypertension and Prehypertension and the Underlying Mechanism: a Randomized Controlled Trial
Who cites it
757 citing papers in PubMed, 6 syntheses or guidelines pooled it, 1,265 citations in OpenAlex.
- Functional Equivalence and Conserved Sexual Dimorphism in the Gut Microbiome: A Cross-Species Meta-analysis.Journal of molecular evolution · 2026Pooled it
- Dietary salt intake and cardiovascular outcomes: an umbrella review of meta-analyses and dose-response evidence.Annals of medicine · 2025Pooled it
- The role of gut microbiota in hypertension-mediated organ damage (HMOD): a systematic review.Journal of translational medicine · 2025Pooled it
- Prebiotics Improve Blood Pressure Control by Modulating Gut Microbiome Composition and Function: A Systematic Review and Meta-Analysis.Nutrients · 2025Pooled it
- Exploring the research progression and evolutionary trends of gut microbiome and hypertension: a bibliometric analysis.Frontiers in microbiology · 2025Pooled it
- Angiotensin converting enzyme inhibitors and angiotensin receptor blockers impact on the gut microbiome: a systematic review.Frontiers in endocrinology · 2025Pooled it
- Gut microbiota-derived metabolite isovalerylcarnitine modulates salt sensitivity of blood pressure and incident hypertension: a multicenter dietary salt intervention trial.Nature communications · 2025Trial
- Fecal microbiota transplantation for hypertension: an exploratory, multicenter, randomized, blinded, placebo-controlled trial.Microbiome · 2025Trial
- Gut microbiota signatures in primary aldosteronism and functional identification of an aldosterone-degrading gut bacterium.Gut microbes · 2026Article
- A helminth-microbiota metabolic relay promotes disease tolerance.Gut microbes · 2026Article
- Hypertension and gut microbial hydrogenases: a comparison of hydrogen metabolism and etiology.Medical gas research · 2026Article
- Gut dysbiosis, blood pressure regulation, and cardiometabolic risk in polyendocrine metabolic ovarian syndrome (PMOS).Reviews in endocrine & metabolic disorders · 2026Review
- High-Salt Diet Exacerbates Murine Imiquimod-Induced Psoriasis-like Dermatitis via Activation of Serum- and Glucocorticoid-Inducible Kinase 1.International journal of molecular sciences · 2026Article
- Ecology of protection: probiotic biogeography and sepsis prevention in the neonatal intestine.mBio · 2026Article
- Total Water Intake and Periodontitis in Korean Adults: Evidence from a Nationally Representative Survey.Oral health & preventive dentistry · 2026Article
- Classroom microbiome signatures of pest management associate with reduced asthma symptoms.The Journal of allergy and clinical immunology · 2026Article
- The gut microbiome and allograft outcomes: implications for heart transplantation.The Journal of clinical investigation · 2026Review
- Salt and chronic kidney disease.Nature reviews. Nephrology · 2026Review
- Bidirectional Modulation of the Tumor Immune Microenvironment by Gut Microbiota-Derived Indoles: Mechanisms and Therapeutic Potential.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Gut Microbiota in Metabolic Syndrome: Differences in Microbial Signatures and Clinical Profiles.Medicina (Kaunas, Lithuania) · 2026Review
697 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
39 authors at 18 institutions in 3 countries.
Nicola WilckExperimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
Mariana G MatusCenter for Microbiome Informatics and Therapeutics, and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Sean M KearneyCenter for Microbiome Informatics and Therapeutics, and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Scott W OlesenCenter for Microbiome Informatics and Therapeutics, and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Kristoffer ForslundEuropean Molecular Biology Laboratory, Structural and Computational Biology Unit, 69117 Heidelberg, Germany.
Hendrik BartolomaeusExperimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
Stefanie HaaseDepartment of Neurology, Friedrich-Alexander-University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Anja MählerExperimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
András BaloghExperimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
Lajos MarkóExperimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
Olga VvedenskayaMax-Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.
Friedrich H KleinerExperimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
Dmitry TsvetkovExperimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
Lars KlugExperimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
Paul I CosteaEuropean Molecular Biology Laboratory, Structural and Computational Biology Unit, 69117 Heidelberg, Germany.
Shinichi SunagawaEuropean Molecular Biology Laboratory, Structural and Computational Biology Unit, 69117 Heidelberg, Germany.
Lisa MaierEuropean Molecular Biology Laboratory, Genome Biology Unit, 69117 Heidelberg, Germany.
Natalia RakovaExperimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
Valentin SchatzInstitute of Clinical Microbiology and Hygiene, University Hospital of Regensburg, University of Regensburg, 93053 Regensburg, Germany.
Patrick NeubertInstitute of Clinical Microbiology and Hygiene, University Hospital of Regensburg, University of Regensburg, 93053 Regensburg, Germany.
Christian FrätzerLipidomix GmbH, 13125 Berlin, Germany.
Alexander KrannichBerlin Institute of Health (BIH), Berlin, Germany.
Maik GollaschExperimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
Diana A GrohmeTranslational Immunology, Department of Clinical Pathobiochemistry, Medical Faculty Carl Gustav Carus, Technical University of Dresden, 01307 Dresden, Germany.
Beatriz F Côrte-RealVIB Laboratory of Translational Immunomodulation, VIB Center for Inflammation Research (IRC), Hasselt University, Campus Diepenbeek, 3590 Diepenbeek, Belgium.
Roman G GerlachProject Group 5, Robert Koch Institute, 38855 Wernigerode, Germany.
Marijana BasicHannover Medical School, Institute for Laboratory Animal Science and Central Animal Facility, 30625 Hannover, Germany.
Athanasios TypasEuropean Molecular Biology Laboratory, Genome Biology Unit, 69117 Heidelberg, Germany.
Chuan WuExperimental Immunology Branch, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
Jens M TitzeDivision of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Jonathan JantschInstitute of Clinical Microbiology and Hygiene, University Hospital of Regensburg, University of Regensburg, 93053 Regensburg, Germany.
Michael BoschmannExperimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
Ralf DechendExperimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
Markus KleinewietfeldTranslational Immunology, Department of Clinical Pathobiochemistry, Medical Faculty Carl Gustav Carus, Technical University of Dresden, 01307 Dresden, Germany.
Stefan KempaMax-Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.
Peer BorkMax-Delbrück Center for Molecular Medicine in the Helmholtz Association, 13125 Berlin, Germany.
Ralf A LinkerDepartment of Neurology, Friedrich-Alexander-University Erlangen-Nuremberg, 91054 Erlangen, Germany.
Eric J AlmCenter for Microbiome Informatics and Therapeutics, and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Dominik N MüllerExperimental and Clinical Research Center, a joint cooperation of Max-Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin, 13125 Berlin, Germany.
Max Delbrück Center · DECharité - Universitätsmedizin Berlin · DEBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DEMassachusetts Institute of Technology · USEuropean Molecular Biology Laboratory · DEEuropean Molecular Biology Laboratory · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversity Hospital Carl Gustav Carus · DEUniversity Hospital Regensburg · DEGerman Centre for Cardiovascular Research · DEHasselt University · BELipidomix (Germany) · DEMedizinische Hochschule Hannover · DENational Cancer Institute · USRobert Koch Institute · DEUniversity of Regensburg · DEUniversity of Würzburg · DEVanderbilt University · US
Funding
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MEuropean Research Council 640116NIDDK NIH HHS P30 DK043351
Abstract
A Western lifestyle with high salt consumption can lead to hypertension and cardiovascular disease. High salt may additionally drive autoimmunity by inducing T helper 17 (T
Indexed as
AnimalsAutoimmunityBlood PressureDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalFecesGastrointestinal MicrobiomeHumansHypertensionIndoleacetic AcidsIndolesIntestinesLactobacillusLymphocyte ActivationLymphocyte CountMaleindole-3-lactic acidindoleacetic acidIndoleacetic AcidsIndolesSodium ChlorideTryptophan
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT02509962ClinicalTrials.gov
NCT05095350ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.