Evidence map›Paper›PMID 29143805›Full record

SynthesisInternational journal of molecular sciences2017

Mechanisms of Acupuncture Therapy in Ischemic Stroke Rehabilitation: A Literature Review of Basic Studies.

Lina M Chavez, Shiang-Suo Huang, Iona MacDonald, Jaung-Geng Lin, Yu-Chen Lee, Yi-Hung Chen

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04771169 (Comparison of Vestibular Rehabilitation With Virtual Reality on Dizziness, Balance and Gait in Subacute Stroke Patients), which is not on this map. Cited by 205 papers, 30 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
205citing papers in PubMed, 30 pooled it
22.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04771169 nacompletednot on this mapstarted 2021, after this paper: background citation

Comparison of Vestibular Rehabilitation With Virtual Reality on Dizziness, Balance and Gait in Subacute Stroke Patients

TypeinterventionalSponsorRiphah International UniversityRan2021 to 2021Enrolled34ConditionsVestibular RehabilitationArmsvestibular Training Group, Virtual Reality Group
3 · Its place in the literature

Who cites it

205 citing papers in PubMed, 30 syntheses or guidelines pooled it, 374 citations in OpenAlex.

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145 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Lina M ChavezGraduate Institute of Acupuncture Science, China Medical University, Taichung 40402, Taiwan. linita_salamanca@hotmail.com.
Shiang-Suo HuangDepartment of Pharmacology and Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung 40402, Taiwan. sshuang@csmu.edu.tw.
Iona MacDonaldGraduate Institute of Acupuncture Science, China Medical University, Taichung 40402, Taiwan. iona2005@mail.cmu.edu.tw.
Jaung-Geng LinSchool of Chinese Medicine, China Medical University, Taichung 40402, Taiwan. jglin@mail.cmu.edu.tw.
Yu-Chen LeeGraduate Institute of Acupuncture Science, China Medical University, Taichung 40402, Taiwan. d5167@mail.cmuh.org.tw.
Yi-Hung ChenGraduate Institute of Acupuncture Science, China Medical University, Taichung 40402, Taiwan. yihungchen@mail.cmu.edu.tw.
China Medical University · TWChina Medical University Hospital · TWChung Shan Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acupuncture is recommended by the World Health Organization (WHO) as an alternative and complementary strategy for stroke treatment and for improving stroke care. Clinical trial and meta-analysis findings have demonstrated the efficacy of acupuncture in improving balance function, reducing spasticity, and increasing muscle strength and general well-being post-stroke. The mechanisms underlying the beneficial effects of acupuncture in stroke rehabilitation remain unclear. The aim of this study was to conduct a literature review, summarize the current known mechanisms in ischemic stroke rehabilitation through acupuncture and electroacupuncture (EA) therapy, and to detail the frequently used acupoints implicated in these effects. The evidence in this review indicates that five major different mechanisms are involved in the beneficial effects of acupuncture/EA on ischemic stroke rehabilitation: (1) Promotion of neurogenesis and cell proliferation in the central nervous system (CNS); (2) Regulation of cerebral blood flow in the ischemic area; (3) Anti-apoptosis in the ischemic area; (4) Regulation of neurochemicals; and, (5) Improvement of impaired long-term potentiation (LTP) and memory after stroke. The most frequently used acupoints in basic studies include Baihui (GV20), Zusanli (ST36), Quchi (LI11), Shuigou (GV26), Dazhui (GV14), and Hegu (LI4). Our findings show that acupuncture exerts a beneficial effect on ischemic stroke through modulation of different mechanisms originating in the CNS.

Indexed as

Acupuncture TherapyStroke RehabilitationAnimalsApoptosisCell ProliferationCerebrovascular CirculationHumansLong-Term PotentiationMemoryNeovascularization, PhysiologicNeurogenesisNeurotransmitter AgentsStrokeTreatment OutcomeNeurotransmitter Agentsacupuncturebasic researchcerebral ischemiarehabilitationstroke

Identifiers

PMID29143805
PMCPMC5713240
OpenAlexW2766518246

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.