Evidence map›Paper›PMID 29143692›Full record

SynthesisPsychological medicine2018

Non-pharmacological interventions for Lewy body dementia: a systematic review.

Michael H Connors, Lena Quinto, Ian McKeith, Henry Brodaty, Louise Allan, Claire Bamford, Alan Thomas, John-Paul Taylor, John T O'Brien

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Psychological medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Michael H ConnorsSydney Medical School, University of Sydney, Sydney, NSW, Australia.
Lena QuintoSydney Medical School, University of Sydney, Sydney, NSW, Australia.
Ian McKeithInstitute of Neuroscience, Newcastle University, Newcastle, United Kingdom.
Henry BrodatyDementia Centre for Research Collaboration, UNSW Sydney, Sydney, NSW, Australia.
Louise AllanInstitute of Neuroscience, Newcastle University, Newcastle, United Kingdom.
Claire BamfordInstitute of Health and Society, Newcastle University, Newcastle, United Kingdom.
Alan ThomasInstitute of Neuroscience, Newcastle University, Newcastle, United Kingdom.
John-Paul TaylorInstitute of Neuroscience, Newcastle University, Newcastle, United Kingdom.
John T O'BrienDepartment of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
Newcastle University · GBUNSW Sydney · AUUniversity of Cambridge · GBUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lewy body dementia (consisting of dementia with Lewy bodies and Parkinson's disease dementia) is a common neurodegenerative disease characterised by visual hallucinations, fluctuating attention, motor disturbances, falls, and sensitivity to antipsychotics. This combination of features presents challenges for pharmacological management. Given this, we sought to review evidence for non-pharmacological interventions with patients with Lewy body dementia and their carers. Bibliographic databases were searched using a wide range of search terms and no restrictions were placed on study design, language, or clinical setting. Two reviewers independently assessed papers for inclusion, rated study quality, and extracted data. The search identified 21 studies including two randomised controlled trials with available subgroup data, seven case series, and 12 case studies. Most studies reported beneficial effects of the interventions used, though the only sizeable study was on dysphagia, showing a benefit of honey-thickened liquids. Given the heterogeneity of interventions and poor quality of the studies overall, no quantitative synthesis was possible. Overall, identified studies suggested possible benefits of non-pharmacological interventions in Lewy body dementia, but the small sample sizes and low quality of studies mean no definite recommendations can be offered. Our findings underscore the clear and urgent need for future research on this topic.

Indexed as

Electric Stimulation TherapyExercise TherapyHumansLewy Body DiseaseOccupational TherapyOutcome Assessment, Health CarePsychotherapyCaregiver supportdementia with Lewy bodiesLewy body dementianeuropsychiatric symptomsnon-pharmacologicalParkinson's disease dementia

Identifiers

PMID29143692
PMCPMC6088773
OpenAlexW2770155004

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.