Evidence map›Paper›PMID 29143608›Full record

ReviewBMC genomics2017

Physical activity in the prevention of human diseases: role of epigenetic modifications.

Elisa Grazioli, Ivan Dimauro, Neri Mercatelli, Guan Wang, Yannis Pitsiladis, Luigi Di Luigi, Daniela Caporossi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elisa GrazioliDepartment of Movement, Human and Health Sciences, Unit of Biology, Genetics and Biochemistry, University of Rome "Foro Italico", Rome, Italy.
Ivan DimauroDepartment of Movement, Human and Health Sciences, Unit of Biology, Genetics and Biochemistry, University of Rome "Foro Italico", Rome, Italy.
Neri MercatelliDepartment of Movement, Human and Health Sciences, Unit of Biology, Genetics and Biochemistry, University of Rome "Foro Italico", Rome, Italy.
Guan WangFIMS Reference Collaborating Centre of Sports Medicine for Anti-Doping Research, University of Brighton, Brighton, UK.
Yannis PitsiladisDepartment of Movement, Human and Health Sciences, Unit of Biology, Genetics and Biochemistry, University of Rome "Foro Italico", Rome, Italy.
Luigi Di LuigiDepartment of Movement, Human and Health Sciences, Unit of Endocrinology, University of Rome "Foro Italico", Rome, Italy.
Daniela CaporossiDepartment of Movement, Human and Health Sciences, Unit of Biology, Genetics and Biochemistry, University of Rome "Foro Italico", Rome, Italy. daniela.caporossi@uniroma4.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic modification refers to heritable changes in gene function that cannot be explained by alterations in the DNA sequence. The current literature clearly demonstrates that the epigenetic response is highly dynamic and influenced by different biological and environmental factors such as aging, nutrient availability and physical exercise. As such, it is well accepted that physical activity and exercise can modulate gene expression through epigenetic alternations although the type and duration of exercise eliciting specific epigenetic effects that can result in health benefits and prevent chronic diseases remains to be determined. This review highlights the most significant findings from epigenetic studies involving physical activity/exercise interventions known to benefit chronic diseases such as metabolic syndrome, diabetes, cancer, cardiovascular and neurodegenerative diseases.

Indexed as

Epigenesis, GeneticExercisePreventive MedicineDiseaseHumansDisease preventionDNA methylationExerciseHistone modification

Identifiers

PMID29143608
PMCPMC5688489

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.