Evidence map›Paper›PMID 29143484›Full record

Trial reportMolecular nutrition & food research2018

Response of Red Blood Cell Folate to Supplementation in Nonpregnant Women is Predictable: A Proposal for Personalized Supplementation.

Rima Obeid, Christiane Schön, Manfred Wilhelm, Rajiv P Shrestha, Stefan Pilz, Klaus Pietrzik

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Molecular nutrition & food research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rima ObeidDepartment of Clinical Chemistry, Saarland University Hospital, Homburg, Germany.
Christiane SchönBioTeSys GmbH, Esslingen, Germany.
Manfred WilhelmDepartment of Mathematics, Natural and Economic Sciences, University of Applied Sciences Ulm, Ulm, Germany.
Rajiv P ShresthaOctet Research Inc., Boston, MA, USA.
Stefan PilzDivision of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Klaus PietrzikDepartment of Nutrition and Food Science, Rheinische Friedrich-Wilhelms University, Bonn, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

scopeWe modeled red blood cell (RBC)-folate response to supplementation and developed personalized folate supplementation concepts. METHODS AND

resultsThe changes of RBC-folate were modeled in a time- (4 or 8 weeks) and dose- (400 or 800 μg d

conclusionsThe models can guide nutritional recommendations in women when baseline RBC-folate concentrations are measured and the time to pregnancy between 4 and 8 weeks.

Indexed as

Dietary SupplementsAdolescentAdultErythrocytesFemaleFolic AcidHomocysteineHumansMiddle AgedReproducibility of ResultsYoung AdultFolic AcidHomocysteinebirth defectsfolate requirementpregnancyRBC-folatesupplementation

Identifiers

PMID29143484
PMCPMC5838518

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.