ArticleHuman brain mapping2018
Central pain processing in "drug-naïve" pain-free patients with Parkinson's disease.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cerebellar Contribution to Motor and Non-motor Functions in Parkinson's Disease: A Meta-Analysis of fMRI Findings.Frontiers in neurology · 2020Pooled it
- Lateral habenula and periaqueductal gray neurons signal reward prediction error and continuity of reward expectancy to drive reward-seeking behavior.Cell reports · 2026Article
- A cross-sectional study of the association between the lymphocyte to high-density lipoprotein ratio and pain in parkinson's disease.Experimental brain research · 2026Article
- Electrophysiological Evidence for Impaired Central Pain Modulation in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Pain and fatigue in Parkinson's disease: advances in diagnosis and management.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Review
- Periaqueductal gray passes over disappointment and signals continuity of remaining reward expectancy.Research square · 2025Article
- Altered functional activity and connectivity in Parkinson's disease with chronic pain: a resting-state fMRI study.Frontiers in aging neuroscience · 2025Article
- Periaqueductal gray passes over disappointment and signals continuity of remaining reward expectancy.bioRxiv : the preprint server for biology · 2024Article
- Pain in Parkinson's disease: a neuroanatomy-based approach.Brain communications · 2024Review
- Periaqueductal grey and spinal cord pathology contribute to pain in Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Pain Assessment in Chinese Parkinson's Disease Patients Using King's Parkinson's Disease Pain Scale.Journal of pain research · 2022Article
- A Method for the Prediction of Clinical Outcome Using Diffusion Magnetic Resonance Imaging: Application on Parkinson's Disease.Journal of clinical medicine · 2020Article
- An overview of pain in Parkinson's disease.Clinical parkinsonism & related disorders · 2020Article
- A Comparison of Pain between Parkinson's Disease and Multiple System Atrophy: A Clinical Cross-Sectional Survey.Pain research & management · 2019Article
- Central pain processing in "drug-naïve" pain-free patients with Parkinson's disease.Human brain mapping · 2018Article
- Structural and Functional Brain Patterns of Non-Motor Syndromes in Parkinson's Disease.Frontiers in neurology · 2018Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite its clinical relevance, the pathophysiology of pain in Parkinson's disease (PD) is still largely unknown, and both central and peripheral mechanisms have been invoked.
objectivesTo investigate whether central pain processing is altered in "drug-naive" pain-free PD (dnPD) patients.
methodsUsing event-related functional MRI (fMRI), functional response to forearm heat stimulation (FHS) at two different intensities (41°C and 53°C) was investigated in 20 pain-free dnPD patients, compared with 18 healthy controls (HCs). Secondary analyses were performed to evaluate associations between BOLD signal changes and PD clinical features and behavioral responses.
resultsDuring low-innocuous FHS (41°C), no activation differences were found between dnPD patients and HCs. During high-noxious FHS (53°C) a significantly increased activation in the left somatosensory cortex, left cerebellum, and right low pons was observed in dnPD patients compared to HCs. In the latter experimental condition, fMRI BOLD signal changes in the right low pons (p < .0001; R = -0.8) and in the cerebellum (p = .004; R = -0.7) were negatively correlated with pain intensity ratings only in dnPD patients. No statistically significant difference in experimental pain perception was detected between dnPD patients and HCs.
conclusionsOur findings suggest that a functional remodulation of pain processing pathways occurs even in the absence of clinically overt pain symptoms in dnPD patients. These mechanisms may eventually become dysfunctional over time, contributing to the emergence of pain symptoms in more advanced PD stages. The comprehension of pain-related mechanisms may improve the clinical approach and therapeutic management of this disabling nonmotor symptom.
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