Evidence map›Paper›PMID 29143221›Full record

ArticleAMB Express2017

Controlling Streptococcus mutans and Staphylococcus aureus biofilms with direct current and chlorhexidine.

Hao Wang, Dacheng Ren

Open access · goldAbstract read
In one paragraph

Article in AMB Express, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Frontiers in microbiology · 2025
    Article
  5. Article
  6. Article
  7. Zirconia Dental Implants Surface Electric Stimulation Impact onInternational journal of molecular sciences · 2024
    Article
  8. Suppression ofIranian journal of basic medical sciences · 2024
    Article
  9. Article
  10. Antibiotics (Basel, Switzerland) · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Formulation, characteristics and anti-bacterial effects ofJournal of Taibah University Medical Sciences · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Thermal Shock and Ciprofloxacin Act Orthogonally onAntibiotics (Basel, Switzerland) · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hao WangDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY, 13244, USA.
Dacheng RenDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY, 13244, USA. dren@syr.edu.ORCID http://orcid.org/0000-0002-6517-906X
Syracuse University · US

Funding

National Science Foundation EFRI-1137186
6 · The paper itself

Abstract

Microbial biofilms formed on biomaterials are major causes of chronic infections. Among them, Gram-positive bacteria Streptococcus mutans and Staphylococcus aureus are important pathogens causing infections associated with dental caries (tooth-decay) and other medical implants. Unfortunately, current antimicrobial approaches are ineffective in disrupting established biofilms and new methods are needed to improve the efficacy. In this study, we report that the biofilm cells of S. mutans and S. aureus can be effectively killed by low-level direct current (DC) and through synergy in concurrent treatment with DC and chlorhexidine (CHX) at low concentrations. For example, after treatment with 28 µA/cm

Indexed as

BiofilmChlorhexidineElectrochemical controlSynergistic effects

Identifiers

PMID29143221
PMCPMC5688048
OpenAlexW2770185532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.